Abstract
Background: Cannabis withdrawal is not recognized in DSM-IV because of doubts about its clinical significance. Objectives: Assess the phenomenon of cannabis withdrawal and its relationship to relapse in non-treatment-seeking adults. Subjects: Convenience sample of 469 adult cannabis smokers who had made a quit attempt while not in a controlled environment. Methods: Subjects completed a 176-item Marijuana Quit Questionnaire collecting information on sociodemographic characteristics, cannabis use history, and their " most difficult" cannabis quit attempt. Results: 42.4% of subjects had experienced a lifetime withdrawal syndrome, of whom 70.4% reported using cannabis in response to withdrawal. During the index quit attempt, 95.5% of subjects reported ≥1 individual withdrawal symptom (mean [SD] 9.5 [6.1], median 9.0); 43.1% reported ≥10. Number of withdrawal symptoms was significantly associated with greater frequency and amount of cannabis use, but symptoms occurred even in those using less than weekly. Symptoms were usually of ≥ moderate intensity and often prompted actions to relieve them. Alcohol (41.5%) and tobacco (48.2%) were used more often than cannabis (33.3%) for this purpose. There was little change during withdrawal in use of other legal or illegal substances. Conclusions: Cannabis withdrawal is a common syndrome among adults not seeking treatment. The intention to relieve withdrawal symptoms can drive relapse during quit attempts, giving cannabis withdrawal clinical significance as a target of treatment.
Original language | English (US) |
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Pages (from-to) | 120-127 |
Number of pages | 8 |
Journal | Drug and Alcohol Dependence |
Volume | 111 |
Issue number | 1-2 |
DOIs | |
State | Published - Sep 2010 |
Externally published | Yes |
Keywords
- Cannabis
- Marijuana
- Relapse
- Tolerance
- Withdrawal
ASJC Scopus subject areas
- Psychiatry and Mental health
- Toxicology
- Pharmacology
- Pharmacology (medical)