Cancer vaccines

Research output: Contribution to journalArticlepeer-review

166 Scopus citations


1993 represents the 100th anniversary of William Coley's first report of tumor regressions induced by immune system activation in response to bacterial toxins. While many subsequent cancer vaccine trials have yielded tantalizing results, active immunotherapy has not yet become an established modality of cancer therapy. Newer molecular vaccine approaches based on rational immunological principles have resulted in improved systemic antitumor effects in animal models. Ultimately the genetic definition of tumor-specific antigens will allow the development of targeted antigen-specific vaccines for cancer therapy.

Original languageEnglish (US)
Pages (from-to)310-316
Number of pages7
JournalImmunology Today
Issue number6
StatePublished - Jun 1993

ASJC Scopus subject areas

  • Immunology


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