Cancer vaccines

Drew M. Pardoll

doi:10.1016/0165-6147(93)90209-3

Cancer vaccines

Drew M. Pardoll

School of Medicine

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

1993 represents the 100th anniversary of William Coley's first report of tumour regressions induced by immune system activation in response to bacterial toxins. While many subsequent cancer vaccine trials have yielded tantalizing results, active immunotherapy has not yet become an established modality of cancer therapy. Drew Pardoll reviews newer molecular vaccine approaches based on rational immunological principles that have resulted in improved systemic antitumour effects in animal models. Ultimately the genetic definition of tumour-specific antigens will allow the development of targeted antigen-specific vaccines for cancer therapy.

Original language	English (US)
Pages (from-to)	202-208
Number of pages	7
Journal	Trends in Pharmacological Sciences
Volume	14
Issue number	5
DOIs	https://doi.org/10.1016/0165-6147(93)90209-3
State	Published - May 1993

ASJC Scopus subject areas

Toxicology
Pharmacology

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10.1016/0165-6147(93)90209-3

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title = "Cancer vaccines",

abstract = "1993 represents the 100th anniversary of William Coley's first report of tumour regressions induced by immune system activation in response to bacterial toxins. While many subsequent cancer vaccine trials have yielded tantalizing results, active immunotherapy has not yet become an established modality of cancer therapy. Drew Pardoll reviews newer molecular vaccine approaches based on rational immunological principles that have resulted in improved systemic antitumour effects in animal models. Ultimately the genetic definition of tumour-specific antigens will allow the development of targeted antigen-specific vaccines for cancer therapy.",

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AB - 1993 represents the 100th anniversary of William Coley's first report of tumour regressions induced by immune system activation in response to bacterial toxins. While many subsequent cancer vaccine trials have yielded tantalizing results, active immunotherapy has not yet become an established modality of cancer therapy. Drew Pardoll reviews newer molecular vaccine approaches based on rational immunological principles that have resulted in improved systemic antitumour effects in animal models. Ultimately the genetic definition of tumour-specific antigens will allow the development of targeted antigen-specific vaccines for cancer therapy.

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Cancer vaccines

Abstract

ASJC Scopus subject areas

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