Cancer survivorship - Genetic susceptibility and second primary cancers: Research strategies and recommendations

Lois B. Travis; Charles S. Rabkin; Linda Morris Brown; James M. Allan; Blanche P. Alter; Christine B. Ambrosone; Colin B. Begg; Neil Caporaso; Stephen Chanock; Angela DeMichele; William Douglas Figg; Mary K. Gospodarowicz; Eric J. Hall; Michie Hisada; Peter Inskip; Ruth Kleinerman; John B. Little; David Malkin; Andrea K. Ng; Kenneth Offit; Ching Hon Pui; Leslie L. Robison; Nathaniel Rothman; Peter G. Shields; Louise Strong; Toshiyasu Taniguchi; Margaret A. Tucker; Mark H. Greene

doi:10.1093/jnci/djj001

Cancer survivorship - Genetic susceptibility and second primary cancers: Research strategies and recommendations

Lois B. Travis, Charles S. Rabkin, Linda Morris Brown, James M. Allan, Blanche P. Alter, Christine B. Ambrosone, Colin B. Begg, Neil Caporaso, Stephen Chanock, Angela DeMichele, William Douglas Figg, Mary K. Gospodarowicz, Eric J. Hall, Michie Hisada, Peter Inskip, Ruth Kleinerman, John B. Little, David Malkin, Andrea K. Ng, Kenneth OffitChing Hon Pui, Leslie L. Robison, Nathaniel Rothman, Peter G. Shields, Louise Strong, Toshiyasu Taniguchi, Margaret A. Tucker, Mark H. Greene

Research output: Contribution to journal › Comment/debate › peer-review

217 Scopus citations

Abstract

Cancer survivors constitute 3.5% of the United States population, but second primary malignancies among this high-risk group now account for 16% of all cancer incidence. Although few data currently exist regarding the molecular mechanisms for second primary cancers and other late outcomes after cancer treatment, the careful measurement and documentation of potentially carcinogenic treatments (chemotherapy and radiotherapy) provide a unique platform for in vivo research on gene-environment interactions in human carcinogenesis. We review research priorities identified during a National Cancer Institute (NCI)-sponsored workshop entitled "Cancer Survivorship - Genetic Susceptibility and Second Primary Cancers." These priorities include 1) development of a national research infrastructure for studies of cancer survivorship; 2) creation of a coordinated system for biospecimen collection; 3) development of new technology, bioinformatics, and biomarkers; 4) design of new epidemiologic methods; and 5) development of evidence-based clinical practice guidelines. Many of the infrastructure resources and design strategies that would facilitate research in this area also provide a foundation for the study of other important nonneoplastic late effects of treatment and psychosocial concerns among cancer survivors. These research areas warrant high priority to promote NCI's goal of eliminating pain and suffering related to cancer.

Original language	English (US)
Pages (from-to)	15-25
Number of pages	11
Journal	Journal of the National Cancer Institute
Volume	98
Issue number	1
DOIs	https://doi.org/10.1093/jnci/djj001
State	Published - Jan 2006
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

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Travis, L. B., Rabkin, C. S., Brown, L. M., Allan, J. M., Alter, B. P., Ambrosone, C. B., Begg, C. B., Caporaso, N., Chanock, S., DeMichele, A., Figg, W. D., Gospodarowicz, M. K., Hall, E. J., Hisada, M., Inskip, P., Kleinerman, R., Little, J. B., Malkin, D., Ng, A. K., ... Greene, M. H. (2006). Cancer survivorship - Genetic susceptibility and second primary cancers: Research strategies and recommendations. Journal of the National Cancer Institute, 98(1), 15-25. https://doi.org/10.1093/jnci/djj001

Travis, LB, Rabkin, CS, Brown, LM, Allan, JM, Alter, BP, Ambrosone, CB, Begg, CB, Caporaso, N, Chanock, S, DeMichele, A, Figg, WD, Gospodarowicz, MK, Hall, EJ, Hisada, M, Inskip, P, Kleinerman, R, Little, JB, Malkin, D, Ng, AK, Offit, K, Pui, CH, Robison, LL, Rothman, N, Shields, PG, Strong, L, Taniguchi, T, Tucker, MA & Greene, MH 2006, 'Cancer survivorship - Genetic susceptibility and second primary cancers: Research strategies and recommendations', Journal of the National Cancer Institute, vol. 98, no. 1, pp. 15-25. https://doi.org/10.1093/jnci/djj001

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title = "Cancer survivorship - Genetic susceptibility and second primary cancers: Research strategies and recommendations",

abstract = "Cancer survivors constitute 3.5% of the United States population, but second primary malignancies among this high-risk group now account for 16% of all cancer incidence. Although few data currently exist regarding the molecular mechanisms for second primary cancers and other late outcomes after cancer treatment, the careful measurement and documentation of potentially carcinogenic treatments (chemotherapy and radiotherapy) provide a unique platform for in vivo research on gene-environment interactions in human carcinogenesis. We review research priorities identified during a National Cancer Institute (NCI)-sponsored workshop entitled {"}Cancer Survivorship - Genetic Susceptibility and Second Primary Cancers.{"} These priorities include 1) development of a national research infrastructure for studies of cancer survivorship; 2) creation of a coordinated system for biospecimen collection; 3) development of new technology, bioinformatics, and biomarkers; 4) design of new epidemiologic methods; and 5) development of evidence-based clinical practice guidelines. Many of the infrastructure resources and design strategies that would facilitate research in this area also provide a foundation for the study of other important nonneoplastic late effects of treatment and psychosocial concerns among cancer survivors. These research areas warrant high priority to promote NCI's goal of eliminating pain and suffering related to cancer.",

author = "Travis, {Lois B.} and Rabkin, {Charles S.} and Brown, {Linda Morris} and Allan, {James M.} and Alter, {Blanche P.} and Ambrosone, {Christine B.} and Begg, {Colin B.} and Neil Caporaso and Stephen Chanock and Angela DeMichele and Figg, {William Douglas} and Gospodarowicz, {Mary K.} and Hall, {Eric J.} and Michie Hisada and Peter Inskip and Ruth Kleinerman and Little, {John B.} and David Malkin and Ng, {Andrea K.} and Kenneth Offit and Pui, {Ching Hon} and Robison, {Leslie L.} and Nathaniel Rothman and Shields, {Peter G.} and Louise Strong and Toshiyasu Taniguchi and Tucker, {Margaret A.} and Greene, {Mark H.}",

year = "2006",

month = jan,

doi = "10.1093/jnci/djj001",

language = "English (US)",

volume = "98",

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T2 - Research strategies and recommendations

AU - Travis, Lois B.

AU - Rabkin, Charles S.

AU - Brown, Linda Morris

AU - Allan, James M.

AU - Alter, Blanche P.

AU - Ambrosone, Christine B.

AU - Begg, Colin B.

AU - Caporaso, Neil

AU - Chanock, Stephen

AU - DeMichele, Angela

AU - Figg, William Douglas

AU - Gospodarowicz, Mary K.

AU - Hall, Eric J.

AU - Hisada, Michie

AU - Inskip, Peter

AU - Kleinerman, Ruth

AU - Little, John B.

AU - Malkin, David

AU - Ng, Andrea K.

AU - Offit, Kenneth

AU - Pui, Ching Hon

AU - Robison, Leslie L.

AU - Rothman, Nathaniel

AU - Shields, Peter G.

AU - Strong, Louise

AU - Taniguchi, Toshiyasu

AU - Tucker, Margaret A.

AU - Greene, Mark H.

PY - 2006/1

Y1 - 2006/1

N2 - Cancer survivors constitute 3.5% of the United States population, but second primary malignancies among this high-risk group now account for 16% of all cancer incidence. Although few data currently exist regarding the molecular mechanisms for second primary cancers and other late outcomes after cancer treatment, the careful measurement and documentation of potentially carcinogenic treatments (chemotherapy and radiotherapy) provide a unique platform for in vivo research on gene-environment interactions in human carcinogenesis. We review research priorities identified during a National Cancer Institute (NCI)-sponsored workshop entitled "Cancer Survivorship - Genetic Susceptibility and Second Primary Cancers." These priorities include 1) development of a national research infrastructure for studies of cancer survivorship; 2) creation of a coordinated system for biospecimen collection; 3) development of new technology, bioinformatics, and biomarkers; 4) design of new epidemiologic methods; and 5) development of evidence-based clinical practice guidelines. Many of the infrastructure resources and design strategies that would facilitate research in this area also provide a foundation for the study of other important nonneoplastic late effects of treatment and psychosocial concerns among cancer survivors. These research areas warrant high priority to promote NCI's goal of eliminating pain and suffering related to cancer.

AB - Cancer survivors constitute 3.5% of the United States population, but second primary malignancies among this high-risk group now account for 16% of all cancer incidence. Although few data currently exist regarding the molecular mechanisms for second primary cancers and other late outcomes after cancer treatment, the careful measurement and documentation of potentially carcinogenic treatments (chemotherapy and radiotherapy) provide a unique platform for in vivo research on gene-environment interactions in human carcinogenesis. We review research priorities identified during a National Cancer Institute (NCI)-sponsored workshop entitled "Cancer Survivorship - Genetic Susceptibility and Second Primary Cancers." These priorities include 1) development of a national research infrastructure for studies of cancer survivorship; 2) creation of a coordinated system for biospecimen collection; 3) development of new technology, bioinformatics, and biomarkers; 4) design of new epidemiologic methods; and 5) development of evidence-based clinical practice guidelines. Many of the infrastructure resources and design strategies that would facilitate research in this area also provide a foundation for the study of other important nonneoplastic late effects of treatment and psychosocial concerns among cancer survivors. These research areas warrant high priority to promote NCI's goal of eliminating pain and suffering related to cancer.

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ER -

Cancer survivorship - Genetic susceptibility and second primary cancers: Research strategies and recommendations

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