Cancer Stem Cell Metabolism

Fidelia B. Alvina, Arvin M. Gouw, Anne Le

Research output: Chapter in Book/Report/Conference proceedingChapter


Cancer stem cells (CSCs), also known as tumorinitiating cells (TICs), are a group of cells found within cancer cells. Like normal stem cells, CSCs can proliferate, engage in self-renewal, and are often implicated in the recurrence of tumors after therapy [1, 2]. The existence of CSCs in various types of cancer has been proven, such as in acute myeloid leukemia (AML) [3], breast [4], pancreatic [5], and lung cancers [6], to name a few. There are two theories regarding the origin of CSCs. First, CSCs may have arisen from normal stem/progenitor cells that experienced changes in their environment or genetic mutations. On the other hand, CSCs may also have originated from differentiated cells that underwent genetic and/or heterotypic modifications [7]. Either way, CSCs reprogram their metabolism in order to support tumorigenesis.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
Number of pages12
StatePublished - 2021

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019


  • Cancer stem cell
  • Glucose metabolism
  • Glutamine metabolism
  • Lipid metabolism
  • Metabolic plasticity
  • Mitochondrial metabolism

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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