Cancer risk associated with germline DNA mismatch repair gene mutations

Malcolm G. Dunlop, Susan M. Farrington, Andrew D. Carothers, Andrew K. Wyllie, Linda Sharp, John Burn, Bo Liu, Kenneth W. Kinzler, Bert Vogelstein

Research output: Contribution to journalArticlepeer-review

579 Scopus citations


The autosomal dominant syndrome of Hereditary Nonpolyposis Colorectal Cancer (HNPCC) is due to germline DNA mismatch repair gene mutations in most cases. However, the penetrance of such mutations outwith classical HNPCC kindreds is unknown because families studied to date have been specifically selected for research purposes. Using a population-based strategy, we have calculated the lifetime cancer risk associated with germline DNA mismatch repair gene mutations, irrespective of their family history. We identified 67 gene carriers whose risk to age 70 for all cancers was 91% for males and 69% for females. The risk of developing colorectal cancer was significantly greater for males than for females (74% versus 30%, P = 0.006). The risk of uterine cancer (42%) exceeded that for colorectal cancer in females, emphasising the need for uterine screening. Our findings give further insight into the biological effect of defective DNA mismatch repair. We have demonstrated a systematic approach to identifying individuals at high risk of cancer but who may not be part of classical HNPCC families. The risk estimates derived from these analyses provide a rational basis on which to guide genetic counselling and to tailor clinical surveillance.

Original languageEnglish (US)
Pages (from-to)105-110
Number of pages6
JournalHuman molecular genetics
Issue number1
StatePublished - Jan 1997

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)


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