TY - JOUR
T1 - Cancer of the pancreas and drinking water
T2 - A population-based case-control study in Washington county, Maryland
AU - Ijsselmuiden, Carel B.
AU - Gaydos, Charlotte
AU - Feighner, Brian
AU - Novakoski, William L.
AU - Serwadda, David
AU - Caris, Luis H.
AU - Vlahov, David
AU - Comstock, George W.
N1 - Funding Information:
versity School of Hygiene and Public Health, Baltimore, MD Reprint requests to Dr. George W. Comstock, Training Center for Public Health Research, Box 2067, Hagerstown, MD 21742-2067 This study was supported in part by research grant CA 36390 from the National Cancer Institute, a fellowship grant from the WK Kellogg Foundation, and Career Research Award HL 21,670 from the National Heart, Lung, and Blood Institute.
PY - 1992/10/1
Y1 - 1992/10/1
N2 - A case-control study was done to assess a potential association between drinking water and pancreatic cancer in Washington County, Maryland. Cases of pancreatic cancer occurring from 1975 through 1989 were identified from the cancer registry. Controls were selected from the private 1975 census of Washington County. There were 101 cases and 206 controls. Chlorinated municipal water was used as a source of drinking water by 79% of cases and 63% of controls, yielding a significant odds ratio of 2.2. Adjustment for age and smoking had almost no effect on the risk, although both age and smoking were independently associated with an increased risk of pancreatic cancer. Although these findings must be interpreted with caution because of limitations in exposure assessment, these results have implications for the prevention of pancreatic cancer because chlorination of water is so widely practiced.
AB - A case-control study was done to assess a potential association between drinking water and pancreatic cancer in Washington County, Maryland. Cases of pancreatic cancer occurring from 1975 through 1989 were identified from the cancer registry. Controls were selected from the private 1975 census of Washington County. There were 101 cases and 206 controls. Chlorinated municipal water was used as a source of drinking water by 79% of cases and 63% of controls, yielding a significant odds ratio of 2.2. Adjustment for age and smoking had almost no effect on the risk, although both age and smoking were independently associated with an increased risk of pancreatic cancer. Although these findings must be interpreted with caution because of limitations in exposure assessment, these results have implications for the prevention of pancreatic cancer because chlorination of water is so widely practiced.
KW - Case-control studies
KW - Chlorine
KW - Pancreatic neoplasms
KW - Water supply
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U2 - 10.1093/aje/136.7.836
DO - 10.1093/aje/136.7.836
M3 - Article
C2 - 1442749
AN - SCOPUS:0026591896
SN - 0002-9262
VL - 136
SP - 836
EP - 842
JO - American journal of epidemiology
JF - American journal of epidemiology
IS - 7
ER -