Cancer of the esophagus and gastric cardia: Recent advances

G. N J Tytgat, H. Bartelink, R. Bernards, G. Giaccone, J. J B van Lanschot, G. J A Offerhaus, G. J. Peters

Research output: Contribution to journalArticlepeer-review

59 Scopus citations


Esophageal cancer and cancer of the gastric cardia, in particular adenocarcinomas, have shown a rapid and largely unexplained increase in incidence in many developed countries around the world. These diseases have a poor prognosis and current therapies have a modest impact on survival. This review presents recent advances in the epidemiology, etiology, diagnosis, staging, prevention and treatment of resectable and advanced disease. Although significant progress has been made in these areas of research and patient management over the past years, prognosis for most patients diagnosed with esophageal cancer or cancer of the gastric cardia remains poor. New diagnostic procedures, improved surgical procedures, combined treatment modalities and new treatment modalities are being evaluated and may be expected to coutribute to improved patient outcomes and better palliation of symptoms in the future.

Original languageEnglish (US)
Pages (from-to)10-26
Number of pages17
JournalDiseases of the Esophagus
Issue number1
StatePublished - 2004
Externally publishedYes


  • Carcinogenesis
  • Diagnosis
  • Epidemiology
  • Esophageal cancer
  • Gastric neoplasms
  • Therapy

ASJC Scopus subject areas

  • Gastroenterology


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