TY - JOUR
T1 - Cancer incidence by levels of cholesterol
AU - Williams, R. R.
AU - Sorlie, P. D.
AU - Feinleib, M.
AU - McNamara, P. M.
AU - Kannel, W. B.
AU - Dawber, T. R.
PY - 1981
Y1 - 1981
N2 - In 5,209 subjects studied for 24 years in Framingham, Mass, 691 cases of cancer were documented, with histological confirmation for 94%. Predetermined personal characteristics were tested for associations with subsequent occurrence of cancer at specific sites using multiple logistic regression. Significant associations of various cancer sites with cigarette smoking, alcohol use, education, height, weight, and parity agreed with other studies. Serum cholesterol level was inversely associated with incidence of colon cancer and with other sites only in men; these inverse associations were statistically significant after adjustment for age, alcohol consumption, cigarette smoking, education, systolic blood pressure, and relative weight. Association may reflect effects of competing lethal diseases, underlying pathophysiological mechanisms that promote or inhibit development of cancer in men, biologic or social response to early and undiagnosed states of cancer.
AB - In 5,209 subjects studied for 24 years in Framingham, Mass, 691 cases of cancer were documented, with histological confirmation for 94%. Predetermined personal characteristics were tested for associations with subsequent occurrence of cancer at specific sites using multiple logistic regression. Significant associations of various cancer sites with cigarette smoking, alcohol use, education, height, weight, and parity agreed with other studies. Serum cholesterol level was inversely associated with incidence of colon cancer and with other sites only in men; these inverse associations were statistically significant after adjustment for age, alcohol consumption, cigarette smoking, education, systolic blood pressure, and relative weight. Association may reflect effects of competing lethal diseases, underlying pathophysiological mechanisms that promote or inhibit development of cancer in men, biologic or social response to early and undiagnosed states of cancer.
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U2 - 10.1001/jama.245.3.247
DO - 10.1001/jama.245.3.247
M3 - Article
C2 - 7452849
SN - 0098-7484
VL - 245
SP - 247
EP - 252
JO - Journal of the American Medical Association
JF - Journal of the American Medical Association
IS - 3
ER -