Cancer genetics: Tumor suppressor meets oncogene

Eric R. Fearon, Chi V. Dang

Research output: Contribution to journalComment/debatepeer-review

33 Scopus citations

Abstract

The adenomatous polyposis coli (APC) tumor suppressor protein is inactivated by mutations in the majority of colorectal cancers. A recent study has revealed that alterations in the APC signaling pathway can result in the transcriptional activation of the c-MYC gene.

Original languageEnglish (US)
Pages (from-to)R62-R65
JournalCurrent Biology
Volume9
Issue number2
DOIs
StatePublished - Jan 28 1999

ASJC Scopus subject areas

  • General Agricultural and Biological Sciences
  • General Biochemistry, Genetics and Molecular Biology

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