Cancer genetics: Tumor suppressor meets oncogene

Eric R. Fearon; Chi V. Dang

doi:10.1016/S0960-9822(99)80012-8

Cancer genetics: Tumor suppressor meets oncogene

Eric R. Fearon, Chi V. Dang

School of Medicine

Research output: Contribution to journal › Comment/debate › peer-review

33 Scopus citations

Abstract

The adenomatous polyposis coli (APC) tumor suppressor protein is inactivated by mutations in the majority of colorectal cancers. A recent study has revealed that alterations in the APC signaling pathway can result in the transcriptional activation of the c-MYC gene.

Original language	English (US)
Pages (from-to)	R62-R65
Journal	Current Biology
Volume	9
Issue number	2
DOIs	https://doi.org/10.1016/S0960-9822(99)80012-8
State	Published - Jan 28 1999

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
General Agricultural and Biological Sciences

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title = "Cancer genetics: Tumor suppressor meets oncogene",

abstract = "The adenomatous polyposis coli (APC) tumor suppressor protein is inactivated by mutations in the majority of colorectal cancers. A recent study has revealed that alterations in the APC signaling pathway can result in the transcriptional activation of the c-MYC gene.",

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AU - Dang, Chi V.

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N2 - The adenomatous polyposis coli (APC) tumor suppressor protein is inactivated by mutations in the majority of colorectal cancers. A recent study has revealed that alterations in the APC signaling pathway can result in the transcriptional activation of the c-MYC gene.

AB - The adenomatous polyposis coli (APC) tumor suppressor protein is inactivated by mutations in the majority of colorectal cancers. A recent study has revealed that alterations in the APC signaling pathway can result in the transcriptional activation of the c-MYC gene.

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Cancer genetics: Tumor suppressor meets oncogene

Abstract

ASJC Scopus subject areas

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