Cancer genes and the pathways they control

Bert Vogelstein; Kenneth W. Kinzler

doi:10.1038/nm1087

Cancer genes and the pathways they control

Bert Vogelstein, Kenneth W. Kinzler

Research output: Contribution to journal › Review article › peer-review

3105 Scopus citations

Abstract

The revolution in cancer research can be summed up in a single sentence: cancer is, in essence, a genetic disease. In the last decade, many important genes responsible for the genesis of various cancers have been discovered, their mutations precisely identified, and the pathways through which they act characterized. The purposes of this review are to highlight examples of progress in these areas, indicate where knowledge is scarce and point out fertile grounds for future investigation.

Original language	English (US)
Pages (from-to)	789-799
Number of pages	11
Journal	Nature medicine
Volume	10
Issue number	8
DOIs	https://doi.org/10.1038/nm1087
State	Published - Aug 2004

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1038/nm1087

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title = "Cancer genes and the pathways they control",

abstract = "The revolution in cancer research can be summed up in a single sentence: cancer is, in essence, a genetic disease. In the last decade, many important genes responsible for the genesis of various cancers have been discovered, their mutations precisely identified, and the pathways through which they act characterized. The purposes of this review are to highlight examples of progress in these areas, indicate where knowledge is scarce and point out fertile grounds for future investigation.",

author = "Bert Vogelstein and Kinzler, {Kenneth W.}",

note = "Funding Information: The authors thank many colleagues for their critical reading of the manuscript and S. Mousses for sharing results on EphB2 before publication. Work in the authors{\textquoteright} laboratories has been supported by the Ludwig Trust, the National Colorectal Cancer Research Alliance, the Miracle Foundation, the Clayton Fund and US National Institutes of Health grants CA43460, CA57345 and CA62924.",

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N2 - The revolution in cancer research can be summed up in a single sentence: cancer is, in essence, a genetic disease. In the last decade, many important genes responsible for the genesis of various cancers have been discovered, their mutations precisely identified, and the pathways through which they act characterized. The purposes of this review are to highlight examples of progress in these areas, indicate where knowledge is scarce and point out fertile grounds for future investigation.

AB - The revolution in cancer research can be summed up in a single sentence: cancer is, in essence, a genetic disease. In the last decade, many important genes responsible for the genesis of various cancers have been discovered, their mutations precisely identified, and the pathways through which they act characterized. The purposes of this review are to highlight examples of progress in these areas, indicate where knowledge is scarce and point out fertile grounds for future investigation.

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Cancer genes and the pathways they control

Abstract

ASJC Scopus subject areas

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