Abstract
Objective: To study the relationship of maximum cancer core length (MCCL), on targeted biopsy (TB) of magnetic resonance imaging (MRI)-visible index lesions, to volume of that tumour found at radical prostatectomy (RP). Patients and Methods: In all, 205 men undergoing fusion biopsy and RP were divided into two groups: 136 in whom the MCCL came from an index MRI-visible lesion (TB) and 69 in whom MCCL came from a non-targeted lesion (non-targeted biopsy [NTB]). MRI was 3-T multi-parametric and biopsy was via MRI-ultrasonography fusion. Results: In the TB group, MCCL correlated with volume of clinically significant index tumours (ρ = 0.44–0.60, P < 0.01). The correlation was similar for first and repeat biopsy and for transition and peripheral zone lesions (ρ = 0.42–0.49, P < 0.01). No correlations were found in the NTB group. TB MCCL (6–10 and >10 mm) and MRI lesion diameter (>20 mm) were independently associated with tumour volume. TB MCCLs >10 mm and Gleason scores >7 were each associated with pathological T3 disease (odds ratios 5.73 and 5.04, respectively), but MRI lesion diameter lesion was not. Conclusions: MCCL on a TB from an MRI-visible lesion is an independent predictor of both cancer volume and pathological stage. This relationship does not exist for MCCL from a NTB core. Quantifying CCL on MRI-TBs may have a value, not previously described, to risk-stratify patients with prostate cancer before treatment.
Original language | English (US) |
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Pages (from-to) | 275-281 |
Number of pages | 7 |
Journal | BJU International |
Volume | 124 |
Issue number | 2 |
DOIs | |
State | Published - Aug 2019 |
Keywords
- #PCSM
- #ProstateCancer
- magnetic resonance imaging
- tumour volume
ASJC Scopus subject areas
- Urology