Cancer and autoimmunity: Harnessing longitudinal cohorts to probe the link

Giordano Egiziano, Sasha Bernatsky, Ami A. Shah

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations


In many autoimmune rheumatic diseases, there is an increased risk of cancer compared to the general population. While reasons for this increased risk have not been elucidated, it has been hypothesized that the link between cancer and autoimmunity may be bidirectional. For instance, chronic inflammation and damage from the rheumatic disease or its therapies may trigger malignant transformation; conversely, antitumor immune responses targeting cancers may become cross-reactive resulting in autoimmunity. In rare rheumatic diseases, longitudinal observational studies can play a critical role in studying these complex relationships, thereby enabling investigators to quantify the extent of cancer risk, identify unique clinical phenotypes associated with cancer, investigate the biological link between these conditions, and define optimal strategies for screening and treatment of the underlying cancer. In this review, we discuss recent data on cancer in the rheumatic diseases and suggest a research agenda to address several gaps in our current knowledge base.

Original languageEnglish (US)
Pages (from-to)53-62
Number of pages10
JournalBest Practice and Research: Clinical Rheumatology
Issue number1
StatePublished - Feb 1 2016


  • Autoimmunity
  • Cancer
  • Epidemiology
  • Observational cohorts

ASJC Scopus subject areas

  • Rheumatology


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