CaMKII and its role in cardiac arrhythmia: Molecular perspectives

Jeffrey R. Erickson; Mark E. Anderson

doi:10.1111/j.1540-8167.2008.01295.x

CaMKII and its role in cardiac arrhythmia: Molecular perspectives

Jeffrey R. Erickson, Mark E. Anderson

Research output: Contribution to journal › Review article › peer-review

30 Scopus citations

Abstract

CaMKII and Its Role in Cardiac Arrhythmia. Calcium/calmodulin-dependent kinase II (CaMKII) is a multifunctional serine/threonine kinase widely distributed in a number of tissue types. Activation of CaMKII has been linked to important downstream physiological processes, including apoptosis, hypertrophy, and arrhythmia in the heart. Pharmacological or genetic inhibition of CaMKII has been shown to improve health outcomes in a number of animal models. In this review, we summarize the structural and functional properties of CaMKII and detail its role in cardiac arrhythmia, structural heart disease, and sudden death.

Original language	English (US)
Pages (from-to)	1332-1336
Number of pages	5
Journal	Journal of cardiovascular electrophysiology
Volume	19
Issue number	12
DOIs	https://doi.org/10.1111/j.1540-8167.2008.01295.x
State	Published - Dec 2008
Externally published	Yes

Keywords

Arrhythmia
CaMKII
Hypertrophy
Oxidation

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Physiology (medical)

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10.1111/j.1540-8167.2008.01295.x

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abstract = "CaMKII and Its Role in Cardiac Arrhythmia. Calcium/calmodulin-dependent kinase II (CaMKII) is a multifunctional serine/threonine kinase widely distributed in a number of tissue types. Activation of CaMKII has been linked to important downstream physiological processes, including apoptosis, hypertrophy, and arrhythmia in the heart. Pharmacological or genetic inhibition of CaMKII has been shown to improve health outcomes in a number of animal models. In this review, we summarize the structural and functional properties of CaMKII and detail its role in cardiac arrhythmia, structural heart disease, and sudden death.",

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AB - CaMKII and Its Role in Cardiac Arrhythmia. Calcium/calmodulin-dependent kinase II (CaMKII) is a multifunctional serine/threonine kinase widely distributed in a number of tissue types. Activation of CaMKII has been linked to important downstream physiological processes, including apoptosis, hypertrophy, and arrhythmia in the heart. Pharmacological or genetic inhibition of CaMKII has been shown to improve health outcomes in a number of animal models. In this review, we summarize the structural and functional properties of CaMKII and detail its role in cardiac arrhythmia, structural heart disease, and sudden death.

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KW - CaMKII

KW - Hypertrophy

KW - Oxidation

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CaMKII and its role in cardiac arrhythmia: Molecular perspectives

Abstract

Keywords

ASJC Scopus subject areas

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