Call for improved design and reporting in soft tissue sarcoma studies: A systematic review and meta-analysis of chemotherapy and survival outcomes in resectable STS

Alexandra C. Istl; Jessica M. Ruck; Carol D. Morris; Adam S. Levin; Christian F. Meyer; Fabian M. Johnston

doi:10.1002/jso.25401

Call for improved design and reporting in soft tissue sarcoma studies: A systematic review and meta-analysis of chemotherapy and survival outcomes in resectable STS

Alexandra C. Istl, Jessica M. Ruck, Carol D. Morris, Adam S. Levin, Christian F. Meyer, Fabian M. Johnston

School of Medicine

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

New evidence and systemic therapies demand an updated analysis of chemotherapy for soft tissue sarcoma. We completed a meta-analysis of chemotherapy in localized STS, assessing OS, PFS, and local and distant recurrence (local recurrence-free survival [LRFS] and distant recurrence-free survival [DRFS]). Ten studies, totaling 3157 patients, were included. A pooled analysis for 5-year OS, progression-free survival, LRFS, and DRFS showed no benefit of chemotherapy over locoregional therapy alone for all-comers or site-specific STS. We make recommendations to improve outcome reporting and quality indices.

Original language	English (US)
Pages (from-to)	824-835
Number of pages	12
Journal	Journal of Surgical Oncology
Volume	119
Issue number	7
DOIs	https://doi.org/10.1002/jso.25401
State	Published - Jun 1 2019

Keywords

chemotherapy
localized
resectable
soft tissue sarcoma

ASJC Scopus subject areas

Surgery
Oncology

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10.1002/jso.25401

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Call for improved design and reporting in soft tissue sarcoma studies: A systematic review and meta-analysis of chemotherapy and survival outcomes in resectable STS. / Istl, Alexandra C.; Ruck, Jessica M.; Morris, Carol D. et al.
In: Journal of Surgical Oncology, Vol. 119, No. 7, 01.06.2019, p. 824-835.

Research output: Contribution to journal › Review article › peer-review

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abstract = "New evidence and systemic therapies demand an updated analysis of chemotherapy for soft tissue sarcoma. We completed a meta-analysis of chemotherapy in localized STS, assessing OS, PFS, and local and distant recurrence (local recurrence-free survival [LRFS] and distant recurrence-free survival [DRFS]). Ten studies, totaling 3157 patients, were included. A pooled analysis for 5-year OS, progression-free survival, LRFS, and DRFS showed no benefit of chemotherapy over locoregional therapy alone for all-comers or site-specific STS. We make recommendations to improve outcome reporting and quality indices.",

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note = "Funding Information: We have no funding acknowledgments. The authors thank Lingzi Xu and Justin King for their assistance with the translation of other-language records. F.M.J. received salary support as the primary investigator of an Agency for Healthcare Research and Quality grant (1K08HS024736-01). Publisher Copyright: {\textcopyright} 2019 Wiley Periodicals, Inc.",

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AU - Morris, Carol D.

AU - Levin, Adam S.

AU - Meyer, Christian F.

AU - Johnston, Fabian M.

N1 - Funding Information: We have no funding acknowledgments. The authors thank Lingzi Xu and Justin King for their assistance with the translation of other-language records. F.M.J. received salary support as the primary investigator of an Agency for Healthcare Research and Quality grant (1K08HS024736-01). Publisher Copyright: © 2019 Wiley Periodicals, Inc.

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AB - New evidence and systemic therapies demand an updated analysis of chemotherapy for soft tissue sarcoma. We completed a meta-analysis of chemotherapy in localized STS, assessing OS, PFS, and local and distant recurrence (local recurrence-free survival [LRFS] and distant recurrence-free survival [DRFS]). Ten studies, totaling 3157 patients, were included. A pooled analysis for 5-year OS, progression-free survival, LRFS, and DRFS showed no benefit of chemotherapy over locoregional therapy alone for all-comers or site-specific STS. We make recommendations to improve outcome reporting and quality indices.

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Call for improved design and reporting in soft tissue sarcoma studies: A systematic review and meta-analysis of chemotherapy and survival outcomes in resectable STS

Abstract

Keywords

ASJC Scopus subject areas

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