TY - JOUR
T1 - Calculation of entrophy changes in biological processes
T2 - Folding, finding, and oligomerization
AU - Amzel, L. Mario
N1 - Funding Information:
The authors acknowledge the support of the National Science Foundation Science and Technology Center for Biological Timing at the University of Virginia (NSF DIR-8920162), the Clinical Research Center at the University of Virginia (NIH RR-00847), the University of Maryland at the Baltimore Center for Fluorescence Spectroscopy (NIH RR-08119), and the National Institutes of Health (Grant GM-35154).
Funding Information:
Supported by NIGMS Grant GM 51362.
PY - 2000
Y1 - 2000
N2 - Changes in configurational entropy represent one of the major contributions to the thermodynamics of folding, binding, and oligomerization. Methods have been developed to estimate changes in the entropy of the backbone and side chains, and for the loss of translational entropy. These methods have been used in combination with empirical methods that provide estimates of the changes in entropy of solvation as well as estimates of the changes of enthalpy. The results of such calculations are in excellent agreement with experimentally observed values.
AB - Changes in configurational entropy represent one of the major contributions to the thermodynamics of folding, binding, and oligomerization. Methods have been developed to estimate changes in the entropy of the backbone and side chains, and for the loss of translational entropy. These methods have been used in combination with empirical methods that provide estimates of the changes in entropy of solvation as well as estimates of the changes of enthalpy. The results of such calculations are in excellent agreement with experimentally observed values.
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U2 - 10.1016/S0076-6879(00)23366-1
DO - 10.1016/S0076-6879(00)23366-1
M3 - Article
C2 - 10944752
AN - SCOPUS:0033655709
SN - 0076-6879
VL - 323
SP - 167
EP - 177
JO - Methods in Enzymology
JF - Methods in Enzymology
ER -