TY - JOUR
T1 - Calculated prostate carcinoma volume
T2 - The optimal predictor of 3-year prostate specific antigen (PSA) failure free survival after surgery or radiation therapy of patients with pretreatment PSA levels of 4-20 nanograms per milliliter
AU - D'Amico, Anthony V.
AU - Whittington, Richard
AU - Kaplan, Irving
AU - Beard, Clair
AU - Schultz, Delray
AU - Malkowicz, S. Bruce
AU - Wein, Alan
AU - Tomaszewski, John E.
AU - Coleman, C. Norman
N1 - Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 1998/1/15
Y1 - 1998/1/15
N2 - BACKGROUND. In this study, the authors evaluated whether a clinically relevant stratification of prostate specific antigen (PSA) failure free survival (bNED) after definitive local therapy could be made for patients with prostate carcinoma clinically classified as T1 or T2 and pretreatment PSA levels of 4-20 ng/mL. METHODS. Multivariate Cox regression analysis and Kaplan-Meier analysis were performed for clinically localized prostate carcinoma patients who presented with PSA levels of 4-20 ng/mL. Three hundred forty-eight of the patients were managed definitively with conventional external beam radiation therapy (median dose, 67 gray), whereas 547 of the patients were managed definitively with a radical retropubic prostatectomy. The outcome tested was time to posttreatment PSA failure. The clinical predictors evaluated included the standard paradigm (PSA, biopsy Gleason score, and clinical stage); type of local therapy; and a newly defined factor, the calculated prostate cancer volume (cV(Ca)). RESULTS. Time to posttreatment PSA failure was equivalent (P = 0.52) independent of the type of local therapy. The cV(Ca), (P < 0.0001), pretreatment PSA (P = 0.003), and clinical classification of T2c (P = 0.04) remained significant predictors of time to posttreatment PSA failure in multivariate analysis. CONCLUSIONS. The staging system described herein, which is based on cV(Ca), and PSA, may optimize patient selection for definitive local therapy and entry onto randomized clinical trials examining the use of adjuvant hormonal or chemotherapy in patients with clinically localized disease who present with PSA levels of 4-20 ng/mL. Validation of this staging system by other investigators is currently underway.
AB - BACKGROUND. In this study, the authors evaluated whether a clinically relevant stratification of prostate specific antigen (PSA) failure free survival (bNED) after definitive local therapy could be made for patients with prostate carcinoma clinically classified as T1 or T2 and pretreatment PSA levels of 4-20 ng/mL. METHODS. Multivariate Cox regression analysis and Kaplan-Meier analysis were performed for clinically localized prostate carcinoma patients who presented with PSA levels of 4-20 ng/mL. Three hundred forty-eight of the patients were managed definitively with conventional external beam radiation therapy (median dose, 67 gray), whereas 547 of the patients were managed definitively with a radical retropubic prostatectomy. The outcome tested was time to posttreatment PSA failure. The clinical predictors evaluated included the standard paradigm (PSA, biopsy Gleason score, and clinical stage); type of local therapy; and a newly defined factor, the calculated prostate cancer volume (cV(Ca)). RESULTS. Time to posttreatment PSA failure was equivalent (P = 0.52) independent of the type of local therapy. The cV(Ca), (P < 0.0001), pretreatment PSA (P = 0.003), and clinical classification of T2c (P = 0.04) remained significant predictors of time to posttreatment PSA failure in multivariate analysis. CONCLUSIONS. The staging system described herein, which is based on cV(Ca), and PSA, may optimize patient selection for definitive local therapy and entry onto randomized clinical trials examining the use of adjuvant hormonal or chemotherapy in patients with clinically localized disease who present with PSA levels of 4-20 ng/mL. Validation of this staging system by other investigators is currently underway.
KW - Cancer volume
KW - Prognostic factor
KW - Prostate carcinoma
KW - Prostate specific antigen
KW - Staging
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U2 - 10.1002/(SICI)1097-0142(19980115)82:2<342::AID-CNCR14>3.0.CO;2-Z
DO - 10.1002/(SICI)1097-0142(19980115)82:2<342::AID-CNCR14>3.0.CO;2-Z
M3 - Article
C2 - 9445191
AN - SCOPUS:0031974984
SN - 0008-543X
VL - 82
SP - 334
EP - 341
JO - Cancer
JF - Cancer
IS - 2
ER -