Calcium-Antagonist Receptors in Cardiomyopathy

Martin J. Lohse; Harlan F. Weisman; Frederic L. Sax; John A. Wagner; James Porterfield; Charles L. Mcintosh; Myron L. Weisfeldt; Solomon H. Snyder; Stephen E. Epstein

doi:10.1056/NEJM198909073211014

Calcium-Antagonist Receptors in Cardiomyopathy

Martin J. Lohse, Harlan F. Weisman, Frederic L. Sax, John A. Wagner, James Porterfield, Charles L. Mcintosh, Myron L. Weisfeldt, Solomon H. Snyder, Stephen E. Epstein

School of Medicine

Research output: Contribution to journal › Letter › peer-review

Abstract

To the Editor: Wagner et al. (March 23 issue)¹ provide evidence for an association of hypertrophic cardiomyopathy with an increased density of voltage-sensitive calcium channels in the heart. The mean (±SD) number of channels in atrial tissue, as assessed by binding of a calcium antagonist, was 299±108 fmol per milligram of protein in patients with other cardiac disorders and 397 ±104 fmol per milligram of protein in patients with hypertrophic cardiomyopathy. However, the authors may have overlooked an additional factor determining the number of binding sites for calcium antagonists: previous treatment with these drugs. In the group of patients with.

Original language	English (US)
Pages (from-to)	686-687
Number of pages	2
Journal	New England Journal of Medicine
Volume	321
Issue number	10
DOIs	https://doi.org/10.1056/NEJM198909073211014
State	Published - Sep 7 1989

ASJC Scopus subject areas

Medicine(all)

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title = "Calcium-Antagonist Receptors in Cardiomyopathy",

abstract = "To the Editor: Wagner et al. (March 23 issue)1 provide evidence for an association of hypertrophic cardiomyopathy with an increased density of voltage-sensitive calcium channels in the heart. The mean (±SD) number of channels in atrial tissue, as assessed by binding of a calcium antagonist, was 299±108 fmol per milligram of protein in patients with other cardiac disorders and 397 ±104 fmol per milligram of protein in patients with hypertrophic cardiomyopathy. However, the authors may have overlooked an additional factor determining the number of binding sites for calcium antagonists: previous treatment with these drugs. In the group of patients with.",

author = "Lohse, {Martin J.} and Weisman, {Harlan F.} and Sax, {Frederic L.} and Wagner, {John A.} and James Porterfield and Mcintosh, {Charles L.} and Weisfeldt, {Myron L.} and Snyder, {Solomon H.} and Epstein, {Stephen E.}",

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T1 - Calcium-Antagonist Receptors in Cardiomyopathy

AU - Lohse, Martin J.

AU - Weisman, Harlan F.

AU - Sax, Frederic L.

AU - Wagner, John A.

AU - Porterfield, James

AU - Mcintosh, Charles L.

AU - Weisfeldt, Myron L.

AU - Snyder, Solomon H.

AU - Epstein, Stephen E.

PY - 1989/9/7

Y1 - 1989/9/7

N2 - To the Editor: Wagner et al. (March 23 issue)1 provide evidence for an association of hypertrophic cardiomyopathy with an increased density of voltage-sensitive calcium channels in the heart. The mean (±SD) number of channels in atrial tissue, as assessed by binding of a calcium antagonist, was 299±108 fmol per milligram of protein in patients with other cardiac disorders and 397 ±104 fmol per milligram of protein in patients with hypertrophic cardiomyopathy. However, the authors may have overlooked an additional factor determining the number of binding sites for calcium antagonists: previous treatment with these drugs. In the group of patients with.

AB - To the Editor: Wagner et al. (March 23 issue)1 provide evidence for an association of hypertrophic cardiomyopathy with an increased density of voltage-sensitive calcium channels in the heart. The mean (±SD) number of channels in atrial tissue, as assessed by binding of a calcium antagonist, was 299±108 fmol per milligram of protein in patients with other cardiac disorders and 397 ±104 fmol per milligram of protein in patients with hypertrophic cardiomyopathy. However, the authors may have overlooked an additional factor determining the number of binding sites for calcium antagonists: previous treatment with these drugs. In the group of patients with.

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Calcium-Antagonist Receptors in Cardiomyopathy

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