Calcium action potentials in hair cells pattern auditory neuron activity before hearing onset

Nicolas X. Tritsch; Adrián Rodríguez-Contreras; Tom T.H. Crins; Han Chin Wang; J. Gerard G. Borst; Dwight E. Bergles

doi:10.1038/nn.2604

Calcium action potentials in hair cells pattern auditory neuron activity before hearing onset

Nicolas X. Tritsch
, Adrián Rodríguez-Contreras
, Tom T.H. Crins
, Han Chin Wang
, J. Gerard G. Borst
, Dwight E. Bergles

School of Medicine

Research output: Contribution to journal › Article › peer-review

133 Scopus citations

Abstract

We found rat central auditory neurons to fire action potentials in a precise sequence of mini-bursts before the age of hearing onset. This stereotyped pattern was initiated by hair cells in the cochlea, which trigger brief bursts of action potentials in auditory neurons each time they fire a Ca²⁺ spike. By generating theta-like activity, hair cells may limit the influence of synaptic depression in developing auditory circuits and promote consolidation of synapses.

Original language	English (US)
Pages (from-to)	1050-1052
Number of pages	3
Journal	Nature neuroscience
Volume	13
Issue number	9
DOIs	https://doi.org/10.1038/nn.2604
State	Published - Sep 2010

ASJC Scopus subject areas

General Neuroscience

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10.1038/nn.2604

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title = "Calcium action potentials in hair cells pattern auditory neuron activity before hearing onset",

abstract = "We found rat central auditory neurons to fire action potentials in a precise sequence of mini-bursts before the age of hearing onset. This stereotyped pattern was initiated by hair cells in the cochlea, which trigger brief bursts of action potentials in auditory neurons each time they fire a Ca2+ spike. By generating theta-like activity, hair cells may limit the influence of synaptic depression in developing auditory circuits and promote consolidation of synapses.",

author = "Tritsch, \{Nicolas X.\} and Adri{\'a}n Rodr{\'i}guez-Contreras and Crins, \{Tom T.H.\} and Wang, \{Han Chin\} and Borst, \{J. Gerard G.\} and Bergles, \{Dwight E.\}",

note = "Funding Information: This work was supported by grants from the US National Center for Research Resources (G12-RR03060) to A.R.-C., the European Union (EUSynapse, LSHM-CT-2005{\textendash}019055), Heinsius Houbolt fund and SenterNovem (The Netherlands, Neuro-Bsik, BSIK 03053) to J.G.G.B., and the US National Institutes of Health (DC008860 and DC009464) to D.E.B.",

year = "2010",

month = sep,

doi = "10.1038/nn.2604",

language = "English (US)",

volume = "13",

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T1 - Calcium action potentials in hair cells pattern auditory neuron activity before hearing onset

AU - Tritsch, Nicolas X.

AU - Rodríguez-Contreras, Adrián

AU - Crins, Tom T.H.

AU - Wang, Han Chin

AU - Borst, J. Gerard G.

AU - Bergles, Dwight E.

N1 - Funding Information: This work was supported by grants from the US National Center for Research Resources (G12-RR03060) to A.R.-C., the European Union (EUSynapse, LSHM-CT-2005–019055), Heinsius Houbolt fund and SenterNovem (The Netherlands, Neuro-Bsik, BSIK 03053) to J.G.G.B., and the US National Institutes of Health (DC008860 and DC009464) to D.E.B.

PY - 2010/9

Y1 - 2010/9

N2 - We found rat central auditory neurons to fire action potentials in a precise sequence of mini-bursts before the age of hearing onset. This stereotyped pattern was initiated by hair cells in the cochlea, which trigger brief bursts of action potentials in auditory neurons each time they fire a Ca2+ spike. By generating theta-like activity, hair cells may limit the influence of synaptic depression in developing auditory circuits and promote consolidation of synapses.

AB - We found rat central auditory neurons to fire action potentials in a precise sequence of mini-bursts before the age of hearing onset. This stereotyped pattern was initiated by hair cells in the cochlea, which trigger brief bursts of action potentials in auditory neurons each time they fire a Ca2+ spike. By generating theta-like activity, hair cells may limit the influence of synaptic depression in developing auditory circuits and promote consolidation of synapses.

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DO - 10.1038/nn.2604

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SP - 1050

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JO - Nature neuroscience

JF - Nature neuroscience

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Calcium action potentials in hair cells pattern auditory neuron activity before hearing onset

Abstract

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