Calcifying odontogenic cyst: Clinicopathological features and immunohistochemical profile of 10 cases

Eduardo Rodrigues Fregnani, Fábio Ramôa Pires, Rivera Daniel Quezada, Ie Ming Shih, Pablo Agustin Vargas, Oslei Paes De Almeida

Research output: Contribution to journalArticlepeer-review

48 Scopus citations


Background: Calcifying odontogenic cyst (COC) is an uncommon odontogenic lesion with few studies describing its immunohistochemical profile and proliferative activity reported in the literature. Methods: Clinical and histological features and immunohistochemical expression of cytokeratins, Mel-CAM (CD146), bcl-2, PCNA and ki-67, in 10 cases of COC were studied. Results: All 10 cases affected the maxilla, eight intraosseous and two peripheral. Five central cases were cystic and three were cystic associated with odontoma, and the two extraosseous showed solid histological pattern; immunohistochemistry was positive for cytokeratins 8, 14, 19, AE1/AE3 and 34βE12 and bcl-2 in all cases, and Mel-CAM in six cases. Proliferative activity was greater in the epithelium of central cystic COC in relation to COC associated with odontoma and peripheral lesions. Conclusion: Calcifying odontogenic cysts showed odontogenic cytokeratin profile and bcl-2 and Mel-CAM expression indicate that these proteins may be involved in the development of COC. There were no recurrences after surgery, irrespective of their proliferative activity.

Original languageEnglish (US)
Pages (from-to)163-170
Number of pages8
JournalJournal of Oral Pathology and Medicine
Issue number3
StatePublished - Mar 2003


  • CD146
  • Calcifying odontogenic cyst
  • Cytokeratins
  • Ghost cells
  • Immunohistochemistry
  • Mel-CAM

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Oral Surgery
  • Otorhinolaryngology
  • Cancer Research
  • Periodontics


Dive into the research topics of 'Calcifying odontogenic cyst: Clinicopathological features and immunohistochemical profile of 10 cases'. Together they form a unique fingerprint.

Cite this