Caffeine reversal of sleep deprivation effects on alertness and mood

David Penetar, Una McCann, David Thorne, Gary Kamimori, Cynthia Galinski, Helen Sing, Maria Thomas, Gregory Belenky

Research output: Contribution to journalArticlepeer-review

157 Scopus citations


This study assessed the ability of high doses of caffeine to reverse changes in alertness and mood produced by prolonged sleep deprivation. Fifty healthy, nonsmoking males between the ages of 18 and 32 served as volunteers. Following 49 h without sleep, caffeine (0, 150, 300, or 600 mg/70 kg, PO) was administered in a double-blind fashion. Measures of alertness were obtained with sleep onset tests, the Stanford Sleepiness Scale (SSS), and Visual Analog Scales (VAS). Sleep deprivation decreased onset to sleep from a rested average of 19.9 min to 7 min. Following the highest dose of caffeine tested, sleep onset averaged just over 10 min; sleep onset for the placebo group averaged 5 min. Scores on the SSS increased from a rested mean of 1.6-4.8 after sleep deprivation. Caffeine reduced this score to near rested values. Caffeine reversed sleep deprivation-induced changes in three subscales of the POMS (vigor, fatigue, and confusion) and produced values close to fully rested conditions on several VAS. Serum caffeine concentrations peaked 90 min after ingestion and remained elevated for 12 h. This study showed that caffeine was able to produce significant alerting and long-lasting beneficial mood effects in individuals deprived of sleep for 48 h.

Original languageEnglish (US)
Pages (from-to)359-365
Number of pages7
Issue number2-3
StatePublished - Sep 1 1993
Externally publishedYes


  • Caffeine
  • Humans
  • Profile of Mood States
  • Serm concentration
  • Sleep deprivation
  • Stimulant
  • Visual Analog Scales

ASJC Scopus subject areas

  • Pharmacology


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