D. P. Evatt, R. R. Griffiths

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Caffeine, an adenosine antagonist, is the most widely used mood-altering drug in the world. Caffeine is rapidly absorbed and distributed throughout the body with peak plasma concentrations typically reached 30-45 min after ingestion. The average half-life of caffeine is 4-6 h. Genetics account for some of the variability in responses to caffeine and individual differences in caffeine pharmacokinetics. Caffeine can function as a reinforcer and produces a wide range of physiological, behavioral, and subjective effects, including anxiety, insomnia, diuresis, alertness, and enhancement in some types of performance. Regular caffeine consumption can produce tolerance, withdrawal, and a substance dependence syndrome.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Human Nutrition
PublisherElsevier Inc.
Number of pages7
ISBN (Electronic)9780123848857
ISBN (Print)9780123750839
StatePublished - Jan 1 2012


  • Anxiety
  • Caffeine
  • Dependence
  • Exercise
  • Genetics
  • Mood
  • Performance
  • Pharmacokinetics
  • Reinforcement
  • Sleep
  • Tolerance
  • Withdrawal

ASJC Scopus subject areas

  • Medicine(all)


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