Caenorhabditis elegans DAF-2 as a Model for Human Insulin Receptoropathies

Keyphrases

• Caenorhabditis Elegans 100%
• Human Insulin 100%
• Phenotypic Outcome 60%
• Million Mutation Project 60%
• Insulin-like 40%
• Insulin Signaling 40%
• Genetic Tools 20%
• Human Disease 20%
• Functional Consequences 20%
• Polymorphism 20%
• Signaling Pathway 20%
• New Allele 20%
• Developmental Pathways 20%
• Gene Editing 20%
• Tyrosine Kinase 20%
• Amino Acid Substitution 20%
• C-terminus 20%
• Receptor Gene 20%
• Disease-causing mutations 20%
• Evolutionary Conservation 20%
• Insulin Receptor 20%
• Evolutionary Relationship 20%
• Pathogenic mutations 20%
• Isoform Function 20%
• Exome Sequencing 20%
• Human Pathogenic 20%
• Cis-regulatory Modules 20%
• Binding Residues 20%
• Dauer 20%
• Allelic Series 20%
• Modeling Human Diseases 20%
• Human Exome 20%
• Uncharacterized 20%
• CRISPR-Cas9 Genome Editing 20%

Biochemistry, Genetics and Molecular Biology

• Caenorhabditis Elegans 100%
• Insulin 100%
• Allele 60%
• Insulin Signaling 40%
• C-Terminus 20%
• Genetics 20%
• Isoform 20%
• Receptor Tyrosine Kinase 20%
• Exome Sequencing 20%
• Wild Type 20%
• Receptor Gene 20%
• Amino Acid Substitution 20%
• Active Site 20%
• Insulin Receptor 20%
• Tyrosine Kinase 20%
• Genome Editing 20%
• CRISPR/Cas9 20%