TY - JOUR
T1 - cADPR induced calcium influx mediates axonal degeneration caused by paclitaxel
AU - Höke, Ahmet
N1 - Publisher Copyright:
© 2022 Höke.
PY - 2022/2/7
Y1 - 2022/2/7
N2 - Activation of the NAD hydrolase domain of Sarm1 mediates axonal degeneration caused by chemotherapy drugs, but the downstream events are unknown. In this issue, Li and colleagues (2021. J. Cell Biol. https://doi.org/10.1083/jcb.202106080) demonstrate that cADPR, a breakdown product of NAD, mediates paclitaxel-induced axonal degeneration by promoting influx of calcium into the axons.
AB - Activation of the NAD hydrolase domain of Sarm1 mediates axonal degeneration caused by chemotherapy drugs, but the downstream events are unknown. In this issue, Li and colleagues (2021. J. Cell Biol. https://doi.org/10.1083/jcb.202106080) demonstrate that cADPR, a breakdown product of NAD, mediates paclitaxel-induced axonal degeneration by promoting influx of calcium into the axons.
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U2 - 10.1083/jcb.202112021
DO - 10.1083/jcb.202112021
M3 - Article
C2 - 35019936
AN - SCOPUS:85123564073
SN - 0021-9525
VL - 221
JO - Journal of Cell Biology
JF - Journal of Cell Biology
IS - 2
M1 - e202112021
ER -