Ca2+ in the control of active intestinal Na and Cl transport: involvement in neurohumoral action.

M. Donowitz

Research output: Contribution to journalReview articlepeer-review

85 Scopus citations


Intracellular Ca2+ is a regulator of active intestinal Na and Cl transport. Most studies have been done with rabbit ileum. Increasing intracellular Ca2+ decreases active Na and Cl absorption and/or stimulates active Cl secretion; lowering intracellular Ca2+ stimulates Na and Cl absorption. Based on studies with microvillus membrane vesicles from rabbit ileum, a direct effect of Ca2+ and calmodulin on linked Na and Cl uptake is established. Intracellular Ca2+ and cAMP affect the same transport processes and act in a nonadditive manner. Intracellular Ca2+ does not act by changing intestinal cAMP or cGMP contents, and increasing cAMP mobilizes intracellular Ca2+. Whether this Ca2+ is involved in regulation of ion transport is not known. The aspects of Ca2+ handling identified as involved in regulation of active intestinal Na and Cl transport include entry of Ca2+ across the basolateral membrane, mobilization of Ca2+ from intracellular stores, and involvement of the Ca2+-binding protein calmodulin. Several neurohumoral substances alter intestinal transport by Ca2+-dependent mechanisms and appear to act primarily by increasing (serotonin, carbachol, substance P, and neurotensin) or decreasing (dopamine) Ca2+ entry across the basolateral membrane of intestinal epithelial cells.

Original languageEnglish (US)
Pages (from-to)G165-177
JournalThe American journal of physiology
Issue number2
StatePublished - Aug 1 1983
Externally publishedYes

ASJC Scopus subject areas

  • Physiology (medical)


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