C1q/TNF-related protein 4 (CTRP4) is a unique secreted protein with two tandem C1q domains that functions in the hypothalamus to modulate food intake and body weight

Mardi S. Byerly; Pia S. Petersen; Santosh Ramamurthy; Marcus M. Seldin; Xia Lei; Elayne Provost; Zhikui Wei; Gabriele V. Ronnett; G. William Wong

doi:10.1074/jbc.M113.506956

C1q/TNF-related protein 4 (CTRP4) is a unique secreted protein with two tandem C1q domains that functions in the hypothalamus to modulate food intake and body weight

Mardi S. Byerly, Pia S. Petersen, Santosh Ramamurthy, Marcus M. Seldin, Xia Lei, Elayne Provost, Zhikui Wei, Gabriele V. Ronnett, G. William Wong

School of Medicine

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Background: CTRP4 is a conserved member of the C1q family of secreted proteins with poorly defined function. Results: CTRP4 acts in the hypothalamus to modulate food intake and body weight by regulating the expression of orexigenic neuropeptide expression. Conclusion: CTRP4 plays a role in food intake regulation. Significance: This study establishes the first known in vivo function of CTRP4.

Original language	English (US)
Pages (from-to)	4055-4069
Number of pages	15
Journal	Journal of Biological Chemistry
Volume	289
Issue number	7
DOIs	https://doi.org/10.1074/jbc.M113.506956
State	Published - Feb 14 2014

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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Byerly, M. S., Petersen, P. S., Ramamurthy, S., Seldin, M. M., Lei, X., Provost, E., Wei, Z., Ronnett, G. V., & Wong, G. W. (2014). C1q/TNF-related protein 4 (CTRP4) is a unique secreted protein with two tandem C1q domains that functions in the hypothalamus to modulate food intake and body weight. Journal of Biological Chemistry, 289(7), 4055-4069. https://doi.org/10.1074/jbc.M113.506956

C1q/TNF-related protein 4 (CTRP4) is a unique secreted protein with two tandem C1q domains that functions in the hypothalamus to modulate food intake and body weight. / Byerly, Mardi S.; Petersen, Pia S.; Ramamurthy, Santosh et al.
In: Journal of Biological Chemistry, Vol. 289, No. 7, 14.02.2014, p. 4055-4069.

Research output: Contribution to journal › Article › peer-review

Byerly, MS, Petersen, PS, Ramamurthy, S, Seldin, MM, Lei, X, Provost, E, Wei, Z, Ronnett, GV & Wong, GW 2014, 'C1q/TNF-related protein 4 (CTRP4) is a unique secreted protein with two tandem C1q domains that functions in the hypothalamus to modulate food intake and body weight', Journal of Biological Chemistry, vol. 289, no. 7, pp. 4055-4069. https://doi.org/10.1074/jbc.M113.506956

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AU - Seldin, Marcus M.

AU - Lei, Xia

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AU - Wei, Zhikui

AU - Ronnett, Gabriele V.

AU - Wong, G. William

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C1q/TNF-related protein 4 (CTRP4) is a unique secreted protein with two tandem C1q domains that functions in the hypothalamus to modulate food intake and body weight

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