C-reactive protein levels increase during HIV-1 disease progression in rakai, Uganda, despite the absence of microbial translocation

Andrew D. Redd, Kevin P. Eaton, Xiangrong Kong, Oliver Laeyendecker, Tom Lutalo, Maria J. Wawer, Ronald H. Gray, David Serwadda, Thomas C. Quinn

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


Introduction: Microbial translocation has been implicated as a contributing factor to the heightened immune activation observed during HIV-1 disease progression. When examined in a longitudinal study of HIV-1 seroconverters in Rakai, Uganda, microbial translocation was not associated with HIV-1 disease progression. However, the role of general immune activation in HIV disease progression in this population was not fully examined. Methods: Longitudinal serum samples of HIV-1 seroconverters in three HIV-1 disease progression groups [long-term nonprogressors (LTNP), standard progressors (SP), and rapid progressors (RP)] from Rakai, Uganda, were tested for levels of C-reactive protein (CRP), a marker for immune activation. Results: CRP levels significantly increased in the SP group (P < 0.0001) but not in the RP group or the LTNP group. CRP levels during the first year post-HIV seroconversion in the RP group were significantly higher than those observed in the LTNP group (P < 0.05). For the entire population, CRP levels negatively correlated with lipopolysaccharide levels (P < 0.05) and were not associated with endotoxin antibody levels. Conclusions: This study suggests that in this population, increased immune activation is significantly associated with HIV-1 disease progression but not microbial translocation.

Original languageEnglish (US)
Pages (from-to)556-559
Number of pages4
JournalJournal of Acquired Immune Deficiency Syndromes
Issue number5
StatePublished - Aug 15 2010


  • Africa
  • HIV disease progression
  • immune activation
  • microbial translocation

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)


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