TY - JOUR
T1 - C-reactive protein in adolescent twins
T2 - Patterns and relationship to adiposity
AU - Wang, Guoying
AU - Christoffel, Katherine Kaufer
AU - Brickman, Wendy J.
AU - Hong, Xiumei
AU - Arguelles, Lester
AU - Zhang, Shanchun
AU - Wang, Binyan
AU - Li, Zhiping
AU - Xing, Houxun
AU - Tang, Gengfu
AU - Zimmerman, Donald
AU - Xu, Xiping
AU - Wang, Xiaobin
PY - 2011/10
Y1 - 2011/10
N2 - Context: Elevated C-reactive protein (CRP) is a marker of cardiovascular risk in adults. Patterns and determinants of CRP in adolescents have not been well described. Objective: This study aimed to determine how CRP varies by age, gender, Tanner stage, and body fat composition in rural Chinese adolescents and to what degree adiposity-CRP associations are attributable to shared genetic and environmental factors. Design and Setting: Data were derived from an ongoing study of metabolic syndrome in a large community-based twin cohort enrolled in Anqing, China. Participants: The study sample included 1180 adolescent twins aged 13-21 yr. Main Outcome Measures: Plasma CRP concentrations were measured by sandwich immunoassay using flow metric xMAP technology. Body fat composition was assessed by dual-energy x-ray absorptiometry. Results: CRP levels linearly increased across age and Tanner stage in males (P ≤ 0.0001), but in females, CRP exhibited no trend after adjusting for fat mass (P > 0.05). For males, the most explanatory measure was body mass index (partial r 2 = 5.2%), whereas percent body fat (partial r 2 = 8.8%) was more explanatory in females. Of the phenotypic correlations between adiposity measures and CRP (0.25- 0.28), 86-89% were attributed to shared genetic factors and 11-14% to common unique environmental factors in both sexes. Conclusions: Adiposity is a strong determinant of CRP even in this relatively lean Chinese population. There is notable gender difference for the CRP pattern and the relationship of CRP with adiposity during adolescence. To a large degree, common genetic factors may underlie the observed adiposity-CRP-phenotypic correlations.
AB - Context: Elevated C-reactive protein (CRP) is a marker of cardiovascular risk in adults. Patterns and determinants of CRP in adolescents have not been well described. Objective: This study aimed to determine how CRP varies by age, gender, Tanner stage, and body fat composition in rural Chinese adolescents and to what degree adiposity-CRP associations are attributable to shared genetic and environmental factors. Design and Setting: Data were derived from an ongoing study of metabolic syndrome in a large community-based twin cohort enrolled in Anqing, China. Participants: The study sample included 1180 adolescent twins aged 13-21 yr. Main Outcome Measures: Plasma CRP concentrations were measured by sandwich immunoassay using flow metric xMAP technology. Body fat composition was assessed by dual-energy x-ray absorptiometry. Results: CRP levels linearly increased across age and Tanner stage in males (P ≤ 0.0001), but in females, CRP exhibited no trend after adjusting for fat mass (P > 0.05). For males, the most explanatory measure was body mass index (partial r 2 = 5.2%), whereas percent body fat (partial r 2 = 8.8%) was more explanatory in females. Of the phenotypic correlations between adiposity measures and CRP (0.25- 0.28), 86-89% were attributed to shared genetic factors and 11-14% to common unique environmental factors in both sexes. Conclusions: Adiposity is a strong determinant of CRP even in this relatively lean Chinese population. There is notable gender difference for the CRP pattern and the relationship of CRP with adiposity during adolescence. To a large degree, common genetic factors may underlie the observed adiposity-CRP-phenotypic correlations.
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U2 - 10.1210/jc.2011-0590
DO - 10.1210/jc.2011-0590
M3 - Article
C2 - 21832113
AN - SCOPUS:80053478967
SN - 0021-972X
VL - 96
SP - 3226
EP - 3233
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
IS - 10
ER -