Bupropion Hydrochloride

S. R. Khan, R. T. Berendt, C. D. Ellison, A. B. Ciavarella, E. Asafu-Adjaye, M. A. Khan, P. J. Faustino

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Bupropion hydrochloride is a norepinephrine-dopamine disinhibitor (NDDI) approved for the treatment of depression and smoking cessation. Bupropion is a trimethylated monocyclic phenylaminoketone second-generation antidepressant, which differs structurally from most antidepressants, and resides in a novel mechanistic class that has no direct action on the serotonin system. Comprehensive chemical, physical, and spectroscopic profiles are presented. This analytical profile provides an extensive spectroscopic investigation utilizing mass spectrometry, one- and two-dimensional NMR, solid-state NMR, IR, NIR, Raman, UV, and X-ray diffraction. The profile also includes significant wet chemistry studies for pH, solubility, solution, and plasma stability. Both HPLC and UPLC methodology are presented for bupropion and its related impurities or major metabolites. The profile concludes with an overview of biological properties that includes toxicity, drug metabolism, and pharmacokinetics.

Original languageEnglish (US)
Pages (from-to)1-30
Number of pages30
JournalProfiles of Drug Substances, Excipients and Related Methodology
StatePublished - 2016
Externally publishedYes


  • Aminoketone
  • Antidepressant
  • Bupropion hydrochloride
  • Norepinephrine-dopamine disinhibitor and stability

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Medicine(all)


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