Broadly neutralizing antibodies and the search for an HIV-1 vaccine: The end of the beginning

Peter D. Kwong; John R. Mascola; Gary J. Nabel

doi:10.1038/nri3516

Broadly neutralizing antibodies and the search for an HIV-1 vaccine: The end of the beginning

Peter D. Kwong, John R. Mascola, Gary J. Nabel

Research output: Contribution to journal › Article › peer-review

242 Scopus citations

Abstract

The field of HIV-1 vaccine research has seen a renaissance with the identification of antibodies that neutralize most circulating HIV-1 strains. An understanding of the structural mode of target recognition that these antibodies use and the immune pathways that lead to their development is emerging. This knowledge has provided fundamental insights into the pathways that elicit broadly neutralizing antibodies and provides a foundation for active and passive immunization strategies to prevent HIV-1 infection.

Original language	English (US)
Pages (from-to)	693-701
Number of pages	9
Journal	Nature Reviews Immunology
Volume	13
Issue number	9
DOIs	https://doi.org/10.1038/nri3516
State	Published - Aug 2013
Externally published	Yes

ASJC Scopus subject areas

Immunology

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10.1038/nri3516

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abstract = "The field of HIV-1 vaccine research has seen a renaissance with the identification of antibodies that neutralize most circulating HIV-1 strains. An understanding of the structural mode of target recognition that these antibodies use and the immune pathways that lead to their development is emerging. This knowledge has provided fundamental insights into the pathways that elicit broadly neutralizing antibodies and provides a foundation for active and passive immunization strategies to prevent HIV-1 infection.",

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Broadly neutralizing antibodies and the search for an HIV-1 vaccine: The end of the beginning

Abstract

ASJC Scopus subject areas

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