Brief Report: Willingness to Accept HIV-Infected and Increased Infectious Risk Donor Organs Among Transplant Candidates Living With HIV

Shanti M. Seaman; Sarah E. Van Pilsum Rasmussen; Anh Q. Nguyen; Samantha E. Halpern; Susan You; Madeleine M. Waldram; Saad K. Anjum; Mary Grace Bowring; Abimereki D. Muzaale; Darin B. Ostrander; Diane Brown; Allan B. Massie; Aaron A.R. Tobian; MacEy L. Henderson; Faith E. Fletcher; Burke Smith; Ada Chao; Nishita Gorupati; Katya Prakash; Saima Aslam; Dong H. Lee; Varvara Kirchner; Timothy L. Pruett; Ghady Haidar; Kailey Hughes; Maricar Malinis; Sonya Trinh; Dorry L. Segev; Jeremy Sugarman; Christine M. Durand

doi:10.1097/QAI.0000000000002405

Brief Report: Willingness to Accept HIV-Infected and Increased Infectious Risk Donor Organs Among Transplant Candidates Living With HIV

Shanti M. Seaman, Sarah E. Van Pilsum Rasmussen, Anh Q. Nguyen, Samantha E. Halpern, Susan You, Madeleine M. Waldram, Saad K. Anjum, Mary Grace Bowring, Abimereki D. Muzaale, Darin B. Ostrander, Diane Brown, Allan B. Massie, Aaron A.R. Tobian, MacEy L. Henderson, Faith E. Fletcher, Burke Smith, Ada Chao, Nishita Gorupati, Katya Prakash, Saima AslamDong H. Lee, Varvara Kirchner, Timothy L. Pruett, Ghady Haidar, Kailey Hughes, Maricar Malinis, Sonya Trinh, Dorry L. Segev, Jeremy Sugarman, Christine M. Durand

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Background:HIV-infected (HIV+) donor to HIV+ recipient (HIV D+/R+) transplantation might improve access to transplantation for people living with HIV. However, it remains unknown whether transplant candidates living with HIV will accept the currently unknown risks of HIV D+/R+ transplantation.Methods:We surveyed transplant candidates living with HIV from 9 US transplant centers regarding willingness to accept HIV+ donor organs.Results:Among 116 participants, the median age was 55 years, 68% were men, and 78% were African American. Most were willing to accept HIV+ living donor organs (87%), HIV+ deceased donor organs (84%), and increased infectious risk donor organs (70%). Some (30%) were concerned about HIV superinfection; even among these respondents, 71% were willing to accept an HIV D+ organ. Respondents from centers that had already performed a transplant under an HIV D+/R+ transplantation research protocol were more willing to accept HIV+ deceased donor organs (89% vs. 71%, P = 0.04). Respondents who chose not to enroll in an HIV D+/R+ transplantation research protocol were less likely to believe that HIV D+/R+ transplantation was safe (45% vs. 77%, P = 0.02), and that HIV D+ organs would work similar to HIV D- organs (55% vs. 77%, P = 0.04), but more likely to believe they would receive an infection other than HIV from an HIV D+ organ (64% vs. 13%, P < 0.01).Conclusions:Willingness to accept HIV D+ organs among transplant candidates living with HIV does not seem to be a major barrier to HIV D+/R+ transplantation and may increase with growing HIV D+/R+ transplantation experience.

Original language	English (US)
Pages (from-to)	88-92
Number of pages	5
Journal	Journal of Acquired Immune Deficiency Syndromes
Volume	85
Issue number	1
DOIs	https://doi.org/10.1097/QAI.0000000000002405
State	Published - Sep 1 2020

Keywords

HIV+ organ donation
HIV+ transplantation
HOPE Act
transplantation

ASJC Scopus subject areas

Infectious Diseases
Pharmacology (medical)

Access to Document

10.1097/QAI.0000000000002405

Cite this

Seaman, S. M., Van Pilsum Rasmussen, S. E., Nguyen, A. Q., Halpern, S. E., You, S., Waldram, M. M., Anjum, S. K., Bowring, M. G., Muzaale, A. D., Ostrander, D. B., Brown, D., Massie, A. B., Tobian, A. A. R., Henderson, M. L., Fletcher, F. E., Smith, B., Chao, A., Gorupati, N., Prakash, K., ... Durand, C. M. (2020). Brief Report: Willingness to Accept HIV-Infected and Increased Infectious Risk Donor Organs Among Transplant Candidates Living With HIV. Journal of Acquired Immune Deficiency Syndromes, 85(1), 88-92. https://doi.org/10.1097/QAI.0000000000002405

Brief Report: Willingness to Accept HIV-Infected and Increased Infectious Risk Donor Organs Among Transplant Candidates Living With HIV. / Seaman, Shanti M.; Van Pilsum Rasmussen, Sarah E.; Nguyen, Anh Q. et al.
In: Journal of Acquired Immune Deficiency Syndromes, Vol. 85, No. 1, 01.09.2020, p. 88-92.

Research output: Contribution to journal › Article › peer-review

Seaman, SM, Van Pilsum Rasmussen, SE, Nguyen, AQ, Halpern, SE, You, S, Waldram, MM, Anjum, SK, Bowring, MG, Muzaale, AD , Ostrander, DB, Brown, D, Massie, AB, Tobian, AAR, Henderson, ML, Fletcher, FE, Smith, B, Chao, A, Gorupati, N, Prakash, K, Aslam, S, Lee, DH, Kirchner, V, Pruett, TL, Haidar, G, Hughes, K, Malinis, M, Trinh, S, Segev, DL, Sugarman, J & Durand, CM 2020, 'Brief Report: Willingness to Accept HIV-Infected and Increased Infectious Risk Donor Organs Among Transplant Candidates Living With HIV', Journal of Acquired Immune Deficiency Syndromes, vol. 85, no. 1, pp. 88-92. https://doi.org/10.1097/QAI.0000000000002405

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title = "Brief Report: Willingness to Accept HIV-Infected and Increased Infectious Risk Donor Organs Among Transplant Candidates Living With HIV",

abstract = "Background:HIV-infected (HIV+) donor to HIV+ recipient (HIV D+/R+) transplantation might improve access to transplantation for people living with HIV. However, it remains unknown whether transplant candidates living with HIV will accept the currently unknown risks of HIV D+/R+ transplantation.Methods:We surveyed transplant candidates living with HIV from 9 US transplant centers regarding willingness to accept HIV+ donor organs.Results:Among 116 participants, the median age was 55 years, 68% were men, and 78% were African American. Most were willing to accept HIV+ living donor organs (87%), HIV+ deceased donor organs (84%), and increased infectious risk donor organs (70%). Some (30%) were concerned about HIV superinfection; even among these respondents, 71% were willing to accept an HIV D+ organ. Respondents from centers that had already performed a transplant under an HIV D+/R+ transplantation research protocol were more willing to accept HIV+ deceased donor organs (89% vs. 71%, P = 0.04). Respondents who chose not to enroll in an HIV D+/R+ transplantation research protocol were less likely to believe that HIV D+/R+ transplantation was safe (45% vs. 77%, P = 0.02), and that HIV D+ organs would work similar to HIV D- organs (55% vs. 77%, P = 0.04), but more likely to believe they would receive an infection other than HIV from an HIV D+ organ (64% vs. 13%, P < 0.01).Conclusions:Willingness to accept HIV D+ organs among transplant candidates living with HIV does not seem to be a major barrier to HIV D+/R+ transplantation and may increase with growing HIV D+/R+ transplantation experience.",

keywords = "HIV+ organ donation, HIV+ transplantation, HOPE Act, transplantation",

author = "Seaman, {Shanti M.} and {Van Pilsum Rasmussen}, {Sarah E.} and Nguyen, {Anh Q.} and Halpern, {Samantha E.} and Susan You and Waldram, {Madeleine M.} and Anjum, {Saad K.} and Bowring, {Mary Grace} and Muzaale, {Abimereki D.} and Ostrander, {Darin B.} and Diane Brown and Massie, {Allan B.} and Tobian, {Aaron A.R.} and Henderson, {MacEy L.} and Fletcher, {Faith E.} and Burke Smith and Ada Chao and Nishita Gorupati and Katya Prakash and Saima Aslam and Lee, {Dong H.} and Varvara Kirchner and Pruett, {Timothy L.} and Ghady Haidar and Kailey Hughes and Maricar Malinis and Sonya Trinh and Segev, {Dorry L.} and Jeremy Sugarman and Durand, {Christine M.}",

note = "Funding Information: This work was supported by The Greenwall Foundation Making a Difference grant (J.S.), grant numbers 1P30AI094189 (Johns Hopkins Center for AIDS Research), 1R01AI120938 (A.A.R.T.), U01AI138897 (C.M.D./D.L.S.), and U01AI134591 (C.M.D./D.L.S.) from the National Institute of Allergy and Infectious Diseases, grant number K23CA177321 (C.M.D.) from the National Cancer Institute, and grant numbers K24DK101828 (D.L.S.) and K01DK101677 (A.B.M.) from the National Institute of Diabetes and Digestive and Kidney Diseases. The analyses described here are the responsibility of the authors alone and do not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government. Funding Information: J.S. is a member of Merck KGaA's Bioethics Advisory Panel and Stem Cell Research Oversight Committee, a member of IQVIA's Ethics Advisory Panel; and has consulted for Portola Pharmaceuticals, Inc. D.H.L. has received a research grant from Gilead Sciences, and S.A. has served as a consultant for Merck. These relationships are unrelated to the material described in this manuscript. The remaining authors of this manuscript have no conflicts of interest. Funding Information: This work was supported by The Greenwall Foundation Making a Difference grant (J.S.), grant numbers 1P30AI094189 (Johns Hopkins Center for AIDS Research), 1R01AI120938 (A.A.R.T.), U01AI138897 (C.M.D./D.L.S.), and U01AI134591 (C.M.D./D.L.S.) from the National Institute of Allergy and Infectious Diseases, grant number K23CA177321 (C.M.D.) from the National Cancer Institute, and grant numbers K24DK101828 (D.L.S.) and K01DK101677 (A.B.M.) from the National Institute of Diabetes and Digestive and Kidney Diseases. The analyses described here are the responsibility of the authors alone and do not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government. Publisher Copyright: {\textcopyright} 2020 Lippincott Williams and Wilkins. All rights reserved.",

year = "2020",

month = sep,

day = "1",

doi = "10.1097/QAI.0000000000002405",

language = "English (US)",

volume = "85",

pages = "88--92",

journal = "Journal of Acquired Immune Deficiency Syndromes",

issn = "1525-4135",

publisher = "Lippincott Williams and Wilkins",

number = "1",

}

TY - JOUR

T1 - Brief Report

T2 - Willingness to Accept HIV-Infected and Increased Infectious Risk Donor Organs Among Transplant Candidates Living With HIV

AU - Seaman, Shanti M.

AU - Van Pilsum Rasmussen, Sarah E.

AU - Nguyen, Anh Q.

AU - Halpern, Samantha E.

AU - You, Susan

AU - Waldram, Madeleine M.

AU - Anjum, Saad K.

AU - Bowring, Mary Grace

AU - Muzaale, Abimereki D.

AU - Ostrander, Darin B.

AU - Brown, Diane

AU - Massie, Allan B.

AU - Tobian, Aaron A.R.

AU - Henderson, MacEy L.

AU - Fletcher, Faith E.

AU - Smith, Burke

AU - Chao, Ada

AU - Gorupati, Nishita

AU - Prakash, Katya

AU - Aslam, Saima

AU - Lee, Dong H.

AU - Kirchner, Varvara

AU - Pruett, Timothy L.

AU - Haidar, Ghady

AU - Hughes, Kailey

AU - Malinis, Maricar

AU - Trinh, Sonya

AU - Segev, Dorry L.

AU - Sugarman, Jeremy

AU - Durand, Christine M.

N1 - Funding Information: This work was supported by The Greenwall Foundation Making a Difference grant (J.S.), grant numbers 1P30AI094189 (Johns Hopkins Center for AIDS Research), 1R01AI120938 (A.A.R.T.), U01AI138897 (C.M.D./D.L.S.), and U01AI134591 (C.M.D./D.L.S.) from the National Institute of Allergy and Infectious Diseases, grant number K23CA177321 (C.M.D.) from the National Cancer Institute, and grant numbers K24DK101828 (D.L.S.) and K01DK101677 (A.B.M.) from the National Institute of Diabetes and Digestive and Kidney Diseases. The analyses described here are the responsibility of the authors alone and do not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government. Funding Information: J.S. is a member of Merck KGaA's Bioethics Advisory Panel and Stem Cell Research Oversight Committee, a member of IQVIA's Ethics Advisory Panel; and has consulted for Portola Pharmaceuticals, Inc. D.H.L. has received a research grant from Gilead Sciences, and S.A. has served as a consultant for Merck. These relationships are unrelated to the material described in this manuscript. The remaining authors of this manuscript have no conflicts of interest. Funding Information: This work was supported by The Greenwall Foundation Making a Difference grant (J.S.), grant numbers 1P30AI094189 (Johns Hopkins Center for AIDS Research), 1R01AI120938 (A.A.R.T.), U01AI138897 (C.M.D./D.L.S.), and U01AI134591 (C.M.D./D.L.S.) from the National Institute of Allergy and Infectious Diseases, grant number K23CA177321 (C.M.D.) from the National Cancer Institute, and grant numbers K24DK101828 (D.L.S.) and K01DK101677 (A.B.M.) from the National Institute of Diabetes and Digestive and Kidney Diseases. The analyses described here are the responsibility of the authors alone and do not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government. Publisher Copyright: © 2020 Lippincott Williams and Wilkins. All rights reserved.

PY - 2020/9/1

Y1 - 2020/9/1

N2 - Background:HIV-infected (HIV+) donor to HIV+ recipient (HIV D+/R+) transplantation might improve access to transplantation for people living with HIV. However, it remains unknown whether transplant candidates living with HIV will accept the currently unknown risks of HIV D+/R+ transplantation.Methods:We surveyed transplant candidates living with HIV from 9 US transplant centers regarding willingness to accept HIV+ donor organs.Results:Among 116 participants, the median age was 55 years, 68% were men, and 78% were African American. Most were willing to accept HIV+ living donor organs (87%), HIV+ deceased donor organs (84%), and increased infectious risk donor organs (70%). Some (30%) were concerned about HIV superinfection; even among these respondents, 71% were willing to accept an HIV D+ organ. Respondents from centers that had already performed a transplant under an HIV D+/R+ transplantation research protocol were more willing to accept HIV+ deceased donor organs (89% vs. 71%, P = 0.04). Respondents who chose not to enroll in an HIV D+/R+ transplantation research protocol were less likely to believe that HIV D+/R+ transplantation was safe (45% vs. 77%, P = 0.02), and that HIV D+ organs would work similar to HIV D- organs (55% vs. 77%, P = 0.04), but more likely to believe they would receive an infection other than HIV from an HIV D+ organ (64% vs. 13%, P < 0.01).Conclusions:Willingness to accept HIV D+ organs among transplant candidates living with HIV does not seem to be a major barrier to HIV D+/R+ transplantation and may increase with growing HIV D+/R+ transplantation experience.

AB - Background:HIV-infected (HIV+) donor to HIV+ recipient (HIV D+/R+) transplantation might improve access to transplantation for people living with HIV. However, it remains unknown whether transplant candidates living with HIV will accept the currently unknown risks of HIV D+/R+ transplantation.Methods:We surveyed transplant candidates living with HIV from 9 US transplant centers regarding willingness to accept HIV+ donor organs.Results:Among 116 participants, the median age was 55 years, 68% were men, and 78% were African American. Most were willing to accept HIV+ living donor organs (87%), HIV+ deceased donor organs (84%), and increased infectious risk donor organs (70%). Some (30%) were concerned about HIV superinfection; even among these respondents, 71% were willing to accept an HIV D+ organ. Respondents from centers that had already performed a transplant under an HIV D+/R+ transplantation research protocol were more willing to accept HIV+ deceased donor organs (89% vs. 71%, P = 0.04). Respondents who chose not to enroll in an HIV D+/R+ transplantation research protocol were less likely to believe that HIV D+/R+ transplantation was safe (45% vs. 77%, P = 0.02), and that HIV D+ organs would work similar to HIV D- organs (55% vs. 77%, P = 0.04), but more likely to believe they would receive an infection other than HIV from an HIV D+ organ (64% vs. 13%, P < 0.01).Conclusions:Willingness to accept HIV D+ organs among transplant candidates living with HIV does not seem to be a major barrier to HIV D+/R+ transplantation and may increase with growing HIV D+/R+ transplantation experience.

KW - HIV+ organ donation

KW - HIV+ transplantation

KW - HOPE Act

KW - transplantation

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U2 - 10.1097/QAI.0000000000002405

DO - 10.1097/QAI.0000000000002405

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C2 - 32427721

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JO - Journal of Acquired Immune Deficiency Syndromes

JF - Journal of Acquired Immune Deficiency Syndromes

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Brief Report: Willingness to Accept HIV-Infected and Increased Infectious Risk Donor Organs Among Transplant Candidates Living With HIV

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