Brief Report: Highly Active Antiretroviral Therapy Mitigates Liver Disease in HIV Infection

Jennifer C. Price; Eric C. Seaberg; John P. Phair; Mallory D. Witt; Susan L. Koletar; Chloe L. Thio

doi:10.1097/QAI.0000000000000981

Brief Report: Highly Active Antiretroviral Therapy Mitigates Liver Disease in HIV Infection

Jennifer C. Price, Eric C. Seaberg, John P. Phair, Mallory D. Witt, Susan L. Koletar, Chloe L. Thio

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

To determine the impact of highly active antiretroviral therapy (HAART) on liver disease, we analyzed changes in the aspartate aminotransferase to platelet ratio index (APRI) pre- and post-HAART initiation among 441 HIV-monoinfected and 53 HIV-viral hepatitis-coinfected men. Before HAART, APRI increased 17% and 34% among the HIV-monoinfected and coinfected men, respectively. With HAART initiation, APRI decreased significantly in men who achieved HIV RNA of <500 copies per milliliter: 16% for HIV-monoinfected and 22% for coinfected men. Decreases in APRI were dependent on HIV suppression. This protective effect of HAART decreased after 2 years, particularly in the HIV-monoinfected men.

Original language	English (US)
Pages (from-to)	319-323
Number of pages	5
Journal	Journal of Acquired Immune Deficiency Syndromes
Volume	72
Issue number	3
DOIs	https://doi.org/10.1097/QAI.0000000000000981
State	Published - Jul 1 2016

Keywords

APRI
HBV
HCV
HIV
antiviral therapy
hepatitis
liver

ASJC Scopus subject areas

Infectious Diseases
Pharmacology (medical)

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title = "Brief Report: Highly Active Antiretroviral Therapy Mitigates Liver Disease in HIV Infection",

abstract = "To determine the impact of highly active antiretroviral therapy (HAART) on liver disease, we analyzed changes in the aspartate aminotransferase to platelet ratio index (APRI) pre- and post-HAART initiation among 441 HIV-monoinfected and 53 HIV-viral hepatitis-coinfected men. Before HAART, APRI increased 17% and 34% among the HIV-monoinfected and coinfected men, respectively. With HAART initiation, APRI decreased significantly in men who achieved HIV RNA of <500 copies per milliliter: 16% for HIV-monoinfected and 22% for coinfected men. Decreases in APRI were dependent on HIV suppression. This protective effect of HAART decreased after 2 years, particularly in the HIV-monoinfected men.",

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AU - Phair, John P.

AU - Witt, Mallory D.

AU - Koletar, Susan L.

AU - Thio, Chloe L.

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AB - To determine the impact of highly active antiretroviral therapy (HAART) on liver disease, we analyzed changes in the aspartate aminotransferase to platelet ratio index (APRI) pre- and post-HAART initiation among 441 HIV-monoinfected and 53 HIV-viral hepatitis-coinfected men. Before HAART, APRI increased 17% and 34% among the HIV-monoinfected and coinfected men, respectively. With HAART initiation, APRI decreased significantly in men who achieved HIV RNA of <500 copies per milliliter: 16% for HIV-monoinfected and 22% for coinfected men. Decreases in APRI were dependent on HIV suppression. This protective effect of HAART decreased after 2 years, particularly in the HIV-monoinfected men.

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KW - HBV

KW - HCV

KW - HIV

KW - antiviral therapy

KW - hepatitis

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Brief Report: Highly Active Antiretroviral Therapy Mitigates Liver Disease in HIV Infection

Abstract

Keywords

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