TY - JOUR
T1 - Brief communication
T2 - Urinary excretion by cancer patients of the nucleosides n2, n2-dimethylguanosine, 1-methylinosine, and pseudouridine
AU - Waalkes, T. Phillip
AU - Dinsmore, Stanley R.
AU - Mrochek, John E.
N1 - Funding Information:
2 Supported by Public Health Service contract NIH CA-71-59 from the National Cancer Institute, and the National Institute of General Medical Sciences.
PY - 1973/7
Y1 - 1973/7
N2 - Through high-pressure, high-resolution, liquid ion exchange chromatography, in association with such analytic tools as gas chromatography, gas chromatography-mass spectrometry, and high- and low- resolution mass spectrometry, the nucleosides N2, N2-dimethylguanosine, 1-methylinosine, and pseudouridine, were identified and quantitatively determined in the urine of normal c ontrol subjects and patients with cancer. These nucleosides were derived primarily from transfer RNA, and their excretion reflected the turnover of that macromolecule. In this preliminary study of several types of malignancies, we noted increased excretion of these compounds in at least half of the patients, as compared with normal controls.—J Natl Cancer Inst 51: 271-274, 1973.
AB - Through high-pressure, high-resolution, liquid ion exchange chromatography, in association with such analytic tools as gas chromatography, gas chromatography-mass spectrometry, and high- and low- resolution mass spectrometry, the nucleosides N2, N2-dimethylguanosine, 1-methylinosine, and pseudouridine, were identified and quantitatively determined in the urine of normal c ontrol subjects and patients with cancer. These nucleosides were derived primarily from transfer RNA, and their excretion reflected the turnover of that macromolecule. In this preliminary study of several types of malignancies, we noted increased excretion of these compounds in at least half of the patients, as compared with normal controls.—J Natl Cancer Inst 51: 271-274, 1973.
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U2 - 10.1093/jnci/51.1.271
DO - 10.1093/jnci/51.1.271
M3 - Article
C2 - 4720877
AN - SCOPUS:0015863926
SN - 0027-8874
VL - 51
SP - 271
EP - 274
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
IS - 1
ER -