Breastfeeding associated with higher lung function in African American youths with asthma

Sam S. Oh; Randal Du; Andrew M. Zeiger; Meghan E. McGarry; Donglei Hu; Neeta Thakur; Maria Pino-Yanes; Joshua M. Galanter; Celeste Eng; Katherine Keiko Nishimura; Scott Huntsman; Harold J. Farber; Kelley Meade; Pedro Avila; Denise Serebrisky; Kirsten Bibbins-Domingo; Michael A. Lenoir; Jean G. Ford; Emerita Brigino-Buenaventura; William Rodriguez-Cintron; Shannon M. Thyne; Saunak Sen; Jose R. Rodriguez-Santana; Keoki Williams; Rajesh Kumar; Esteban G. Burchard

doi:10.1080/02770903.2016.1266496

Breastfeeding associated with higher lung function in African American youths with asthma

Sam S. Oh, Randal Du, Andrew M. Zeiger, Meghan E. McGarry, Donglei Hu, Neeta Thakur, Maria Pino-Yanes, Joshua M. Galanter, Celeste Eng, Katherine Keiko Nishimura, Scott Huntsman, Harold J. Farber, Kelley Meade, Pedro Avila, Denise Serebrisky, Kirsten Bibbins-Domingo, Michael A. Lenoir, Jean G. Ford, Emerita Brigino-Buenaventura, William Rodriguez-CintronShannon M. Thyne, Saunak Sen, Jose R. Rodriguez-Santana, Keoki Williams, Rajesh Kumar, Esteban G. Burchard

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Objective: In the United States, Puerto Ricans and African Americans have lower prevalence of breastfeeding and worse clinical outcomes for asthma compared with other racial/ethnic groups. We hypothesize that the history of breastfeeding is associated with increased forced expiratory volume in 1 second (FEV₁) % predicted and reduced asthma exacerbations in Latino and African American youths with asthma. Methods: As part of the Genes-environments & Admixture in Latino Americans (GALA II) Study and the Study of African Americans, asthma, Genes & Environments (SAGE II), we conducted case-only analyses in children and adolescents aged 8–21 years with asthma from four different racial/ethnic groups: African Americans (n = 426), Mexican Americans (n = 424), mixed/other Latinos (n = 255), and Puerto Ricans (n = 629). We investigated the association between any breastfeeding in infancy and FEV¹% predicted using multivariable linear regression; Poisson regression was used to determine the association between breastfeeding and asthma exacerbations. Results: Prevalence of breastfeeding was lower in African Americans (59.4%) and Puerto Ricans (54.9%) compared to Mexican Americans (76.2%) and mixed/other Latinos (66.9%; p < 0.001). After adjusting for covariates, breastfeeding was associated with a 3.58% point increase in FEV₁% predicted (p = 0.01) and a 21% reduction in asthma exacerbations (p = 0.03) in African Americans only. Conclusion: Breastfeeding was associated with higher FEV₁% predicted in asthma and reduced number of asthma exacerbations in African American youths, calling attention to continued support for breastfeeding.

Original language	English (US)
Pages (from-to)	856-865
Number of pages	10
Journal	Journal of Asthma
Volume	54
Issue number	8
DOIs	https://doi.org/10.1080/02770903.2016.1266496
State	Published - Sep 14 2017
Externally published	Yes

Keywords

Asthma
Hispanics
breastfeeding
exacerbations
genetic admixture
lung function
minority

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Immunology and Allergy
Pulmonary and Respiratory Medicine

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Oh, S. S., Du, R., Zeiger, A. M., McGarry, M. E., Hu, D., Thakur, N., Pino-Yanes, M., Galanter, J. M., Eng, C., Nishimura, K. K., Huntsman, S., Farber, H. J., Meade, K., Avila, P., Serebrisky, D., Bibbins-Domingo, K., Lenoir, M. A., Ford, J. G., Brigino-Buenaventura, E., ... Burchard, E. G. (2017). Breastfeeding associated with higher lung function in African American youths with asthma. Journal of Asthma, 54(8), 856-865. https://doi.org/10.1080/02770903.2016.1266496

Oh, SS, Du, R, Zeiger, AM, McGarry, ME, Hu, D, Thakur, N, Pino-Yanes, M, Galanter, JM, Eng, C, Nishimura, KK, Huntsman, S, Farber, HJ, Meade, K, Avila, P, Serebrisky, D, Bibbins-Domingo, K, Lenoir, MA, Ford, JG, Brigino-Buenaventura, E, Rodriguez-Cintron, W, Thyne, SM, Sen, S, Rodriguez-Santana, JR, Williams, K, Kumar, R & Burchard, EG 2017, 'Breastfeeding associated with higher lung function in African American youths with asthma', Journal of Asthma, vol. 54, no. 8, pp. 856-865. https://doi.org/10.1080/02770903.2016.1266496

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title = "Breastfeeding associated with higher lung function in African American youths with asthma",

abstract = "Objective: In the United States, Puerto Ricans and African Americans have lower prevalence of breastfeeding and worse clinical outcomes for asthma compared with other racial/ethnic groups. We hypothesize that the history of breastfeeding is associated with increased forced expiratory volume in 1 second (FEV1) % predicted and reduced asthma exacerbations in Latino and African American youths with asthma. Methods: As part of the Genes-environments & Admixture in Latino Americans (GALA II) Study and the Study of African Americans, asthma, Genes & Environments (SAGE II), we conducted case-only analyses in children and adolescents aged 8–21 years with asthma from four different racial/ethnic groups: African Americans (n = 426), Mexican Americans (n = 424), mixed/other Latinos (n = 255), and Puerto Ricans (n = 629). We investigated the association between any breastfeeding in infancy and FEV1% predicted using multivariable linear regression; Poisson regression was used to determine the association between breastfeeding and asthma exacerbations. Results: Prevalence of breastfeeding was lower in African Americans (59.4%) and Puerto Ricans (54.9%) compared to Mexican Americans (76.2%) and mixed/other Latinos (66.9%; p < 0.001). After adjusting for covariates, breastfeeding was associated with a 3.58% point increase in FEV1% predicted (p = 0.01) and a 21% reduction in asthma exacerbations (p = 0.03) in African Americans only. Conclusion: Breastfeeding was associated with higher FEV1% predicted in asthma and reduced number of asthma exacerbations in African American youths, calling attention to continued support for breastfeeding.",

keywords = "Asthma, Hispanics, breastfeeding, exacerbations, genetic admixture, lung function, minority",

author = "Oh, {Sam S.} and Randal Du and Zeiger, {Andrew M.} and McGarry, {Meghan E.} and Donglei Hu and Neeta Thakur and Maria Pino-Yanes and Galanter, {Joshua M.} and Celeste Eng and Nishimura, {Katherine Keiko} and Scott Huntsman and Farber, {Harold J.} and Kelley Meade and Pedro Avila and Denise Serebrisky and Kirsten Bibbins-Domingo and Lenoir, {Michael A.} and Ford, {Jean G.} and Emerita Brigino-Buenaventura and William Rodriguez-Cintron and Thyne, {Shannon M.} and Saunak Sen and Rodriguez-Santana, {Jose R.} and Keoki Williams and Rajesh Kumar and Burchard, {Esteban G.}",

note = "Publisher Copyright: {\textcopyright} 2017 Taylor & Francis Group, LLC.",

year = "2017",

month = sep,

day = "14",

doi = "10.1080/02770903.2016.1266496",

language = "English (US)",

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pages = "856--865",

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TY - JOUR

T1 - Breastfeeding associated with higher lung function in African American youths with asthma

AU - Oh, Sam S.

AU - Du, Randal

AU - Zeiger, Andrew M.

AU - McGarry, Meghan E.

AU - Hu, Donglei

AU - Thakur, Neeta

AU - Pino-Yanes, Maria

AU - Galanter, Joshua M.

AU - Eng, Celeste

AU - Nishimura, Katherine Keiko

AU - Huntsman, Scott

AU - Farber, Harold J.

AU - Meade, Kelley

AU - Avila, Pedro

AU - Serebrisky, Denise

AU - Bibbins-Domingo, Kirsten

AU - Lenoir, Michael A.

AU - Ford, Jean G.

AU - Brigino-Buenaventura, Emerita

AU - Rodriguez-Cintron, William

AU - Thyne, Shannon M.

AU - Sen, Saunak

AU - Rodriguez-Santana, Jose R.

AU - Williams, Keoki

AU - Kumar, Rajesh

AU - Burchard, Esteban G.

PY - 2017/9/14

Y1 - 2017/9/14

N2 - Objective: In the United States, Puerto Ricans and African Americans have lower prevalence of breastfeeding and worse clinical outcomes for asthma compared with other racial/ethnic groups. We hypothesize that the history of breastfeeding is associated with increased forced expiratory volume in 1 second (FEV1) % predicted and reduced asthma exacerbations in Latino and African American youths with asthma. Methods: As part of the Genes-environments & Admixture in Latino Americans (GALA II) Study and the Study of African Americans, asthma, Genes & Environments (SAGE II), we conducted case-only analyses in children and adolescents aged 8–21 years with asthma from four different racial/ethnic groups: African Americans (n = 426), Mexican Americans (n = 424), mixed/other Latinos (n = 255), and Puerto Ricans (n = 629). We investigated the association between any breastfeeding in infancy and FEV1% predicted using multivariable linear regression; Poisson regression was used to determine the association between breastfeeding and asthma exacerbations. Results: Prevalence of breastfeeding was lower in African Americans (59.4%) and Puerto Ricans (54.9%) compared to Mexican Americans (76.2%) and mixed/other Latinos (66.9%; p < 0.001). After adjusting for covariates, breastfeeding was associated with a 3.58% point increase in FEV1% predicted (p = 0.01) and a 21% reduction in asthma exacerbations (p = 0.03) in African Americans only. Conclusion: Breastfeeding was associated with higher FEV1% predicted in asthma and reduced number of asthma exacerbations in African American youths, calling attention to continued support for breastfeeding.

AB - Objective: In the United States, Puerto Ricans and African Americans have lower prevalence of breastfeeding and worse clinical outcomes for asthma compared with other racial/ethnic groups. We hypothesize that the history of breastfeeding is associated with increased forced expiratory volume in 1 second (FEV1) % predicted and reduced asthma exacerbations in Latino and African American youths with asthma. Methods: As part of the Genes-environments & Admixture in Latino Americans (GALA II) Study and the Study of African Americans, asthma, Genes & Environments (SAGE II), we conducted case-only analyses in children and adolescents aged 8–21 years with asthma from four different racial/ethnic groups: African Americans (n = 426), Mexican Americans (n = 424), mixed/other Latinos (n = 255), and Puerto Ricans (n = 629). We investigated the association between any breastfeeding in infancy and FEV1% predicted using multivariable linear regression; Poisson regression was used to determine the association between breastfeeding and asthma exacerbations. Results: Prevalence of breastfeeding was lower in African Americans (59.4%) and Puerto Ricans (54.9%) compared to Mexican Americans (76.2%) and mixed/other Latinos (66.9%; p < 0.001). After adjusting for covariates, breastfeeding was associated with a 3.58% point increase in FEV1% predicted (p = 0.01) and a 21% reduction in asthma exacerbations (p = 0.03) in African Americans only. Conclusion: Breastfeeding was associated with higher FEV1% predicted in asthma and reduced number of asthma exacerbations in African American youths, calling attention to continued support for breastfeeding.

KW - Asthma

KW - Hispanics

KW - breastfeeding

KW - exacerbations

KW - genetic admixture

KW - lung function

KW - minority

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DO - 10.1080/02770903.2016.1266496

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EP - 865

JO - Journal of Asthma

JF - Journal of Asthma

IS - 8

ER -

Breastfeeding associated with higher lung function in African American youths with asthma

Abstract

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