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- Obstetrics and Gynecology
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In: Obstetrical and Gynecological Survey, Vol. 48, No. 4, 04.1993, p. 246-248.
Research output: Contribution to journal › Comment/debate › peer-review
TY - JOUR
T1 - Breast-feeding and maternal-infant transmission of human immunodeficiency virus type 1
AU - Ruff, Andrea J.
AU - Halsey, Neal A.
AU - Coberly, Jacqueline
AU - Boulos, Reginald
N1 - Funding Information: By 1993 more than 1 million children will have been infected with human immunodeficiency virus type 1, the vast majority acquiring infection from their mothers. 1'2 Most of the infected children reside in developing countries, where the prevalence of HIV-1 infection in women is highest. 1 Interruption of maternal-infant HIV-1 transmission has been hindered by lack of information regarding the timing and precise mechanisms of transmission. Available data suggest that postpartum transmission of HIV-I occurs. 3-13 The purpose of this document is to review and consolidate existing information on postpartum transmission of HIV-1 through breast-feeding and to suggest additional studies to clarify the risks associated with breast-feeding. Apparent transmission of HIV-1 through breast-feeding was first described by Ziegler et al. 3 Since then, 22 infants who probably acquired HIV-1 through breast-feeding have been described. 3~ 3 In almost all instances, seroconversion in the mothers appears to have occurred after delivery, with subsequent infection of their children. In nine of the mothers, seroconversion occurred after postpartum blood transfusions, one mother was an intravenous drug user, and the remaining 12 women were assumed to have acquired HIV-1 through heterosexual transmission. The presumptive mode of maternal-infant HIV-1 transmission in these cases was through breast-feeding, although the possibility that some of the women had been infected before delivery could not be ruled out. Van de Perre et al. ~2 provided the most convincing data in support of HIV-1 transmission through breast-feeding; they identified four women with seroconversion 4 or more months after delivery who apparently transmitted HIV-1 to their infants. It is unlikely that these women were infected at the time of delivery, so breast-feeding was the most likely means of HIV-I transmission. Persons with recent seroconversion and those with advanced Supported in part by grants from the World Health Organization and grant No. 1RO1 A126521 from the National Institutes of Health. This document reflects the opinions of the authors and does not represent official policy of the World Health Organization or the U.S. Public Health Service.
PY - 1993/4
Y1 - 1993/4
UR - http://www.scopus.com/inward/record.url?scp=0027483054&partnerID=8YFLogxK
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U2 - 10.1097/00006254-199304000-00012
DO - 10.1097/00006254-199304000-00012
M3 - Comment/debate
AN - SCOPUS:0027483054
SN - 0029-7828
VL - 48
SP - 246
EP - 248
JO - Obstetrical and Gynecological Survey
JF - Obstetrical and Gynecological Survey
IS - 4