TY - JOUR
T1 - Branched-chain amino acids predict incident diabetes in the Brazilian Longitudinal Study of Adult Health – ELSA-Brasil
AU - de Almeida-Pititto, Bianca
AU - Dualib, Patrícia M.
AU - Jordão, Martha C.
AU - Izar Helfenstein Fonseca, Marília
AU - Jones, Steven R.
AU - Blaha, Michael J.
AU - Toth, Peter P.
AU - Santos, Raul D.
AU - Bensenor, Isabela M.
AU - Ferreira, Sandra Roberta G.
AU - Lotufo, Paulo A.
N1 - Funding Information:
The ELSA-Brasil baseline study was supported by the Brazilian Ministry of Health (Science and Technology Department) and the Brazilian Ministry of Science and Technology and CNPq - National Research Council) (grants # 01 06 0010.00 RS, 01 06 0212.00 BA, 01 06 0300.00 ES, 01 06 0278.00 MG, 01 06 0115.00 SP, 01 06 0071.00 RJ).
Publisher Copyright:
© 2021 Elsevier B.V.
PY - 2021/4
Y1 - 2021/4
N2 - Aims: To evaluate the role of branch chain amino acid (BCAA) concentrations as a predictor for incident type 2 diabetes (DM). Methods: Participants from ELSA-Brasil without diabetes at baseline and followed for 3.9 ± 0.6 years were included in the analysis. The determinations of BCAA (valine, leucine, isoleucine) were performed by proton nuclear magnetic resonance spectroscopy. Cardiometabolic profile and incidence of DM were evaluated according to quartiles of BCAA at baseline, stratified by sex. Results: From 3,828 participants (56% female, 50.5 ± 8.7 years) 299 (8.5%) were diagnosed with DM. For both sexes, a worsening of cardiometabolic profile was observed across increasing BCAA quartiles. In survival analysis, incidence rates of DM for the entire period were highest in participants in the third and fourth quartile of BCAA (log Rank analysis < 0.001 for both sexes). In Cox regression analysis, for men, the HR (95%CI) for risk of DM was 2.24 (1.24–4.03) for those from the fourth quartile of BCAA, while in women it was 1.94 (1.07–3.50), comparing to first quartile of BCAA after adjustments for age, BMI, physical activity, family history of DM, pre-diabetes, blood pressure, total cholesterol and HOMA-IR. Conclusions: Higher levels of BCAA were independently predictors of DM.
AB - Aims: To evaluate the role of branch chain amino acid (BCAA) concentrations as a predictor for incident type 2 diabetes (DM). Methods: Participants from ELSA-Brasil without diabetes at baseline and followed for 3.9 ± 0.6 years were included in the analysis. The determinations of BCAA (valine, leucine, isoleucine) were performed by proton nuclear magnetic resonance spectroscopy. Cardiometabolic profile and incidence of DM were evaluated according to quartiles of BCAA at baseline, stratified by sex. Results: From 3,828 participants (56% female, 50.5 ± 8.7 years) 299 (8.5%) were diagnosed with DM. For both sexes, a worsening of cardiometabolic profile was observed across increasing BCAA quartiles. In survival analysis, incidence rates of DM for the entire period were highest in participants in the third and fourth quartile of BCAA (log Rank analysis < 0.001 for both sexes). In Cox regression analysis, for men, the HR (95%CI) for risk of DM was 2.24 (1.24–4.03) for those from the fourth quartile of BCAA, while in women it was 1.94 (1.07–3.50), comparing to first quartile of BCAA after adjustments for age, BMI, physical activity, family history of DM, pre-diabetes, blood pressure, total cholesterol and HOMA-IR. Conclusions: Higher levels of BCAA were independently predictors of DM.
KW - BCAA
KW - Branched-chain amino acids
KW - Diabetes
KW - Mixed population cohort
KW - Prediction
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U2 - 10.1016/j.diabres.2021.108747
DO - 10.1016/j.diabres.2021.108747
M3 - Article
C2 - 33713721
AN - SCOPUS:85103375270
SN - 0168-8227
VL - 174
JO - Diabetes Research and Clinical Practice
JF - Diabetes Research and Clinical Practice
M1 - 108747
ER -