BrainSeq: Neurogenomics to Drive Novel Target Discovery for Neuropsychiatric Disorders

Christian R. Schubert; Patricio O'Donnell; Jie Quan; Jens R. Wendland; Hualin S. Xi; Ashley R. Winslow; Enrico Domenici; Laurent Essioux; Tony Kam-Thong; David C. Airey; John N. Calley; David A. Collier; Hong Wang; Brian Eastwood; Philip Ebert; Yushi Liu; Laura Nisenbaum; Cara Ruble; James Scherschel; Ryan Matthew Smith; Hui Rong Qian; Kalpana Merchant; Michael Didriksen; Mitsuyuki Matsumoto; Takeshi Saito; Nicholas J. Brandon; Alan J. Cross; Qi Wang; Husseini Manji; Hartmuth Kolb; Maura Furey; Wayne C. Drevets; Joo Heon Shin; Andrew Jaffe; Yankai Jia; Richard E. Straub; Amy Deep-Soboslay; Thomas Hyde; Joel E. Kleinman; Daniel R. Weinberger

doi:10.1016/j.neuron.2015.10.047

BrainSeq: Neurogenomics to Drive Novel Target Discovery for Neuropsychiatric Disorders

Christian R. Schubert, Patricio O'Donnell, Jie Quan, Jens R. Wendland, Hualin S. Xi, Ashley R. Winslow, Enrico Domenici, Laurent Essioux, Tony Kam-Thong, David C. Airey, John N. Calley, David A. Collier, Hong Wang, Brian Eastwood, Philip Ebert, Yushi Liu, Laura Nisenbaum, Cara Ruble, James Scherschel, Ryan Matthew SmithHui Rong Qian, Kalpana Merchant, Michael Didriksen, Mitsuyuki Matsumoto, Takeshi Saito, Nicholas J. Brandon, Alan J. Cross, Qi Wang, Husseini Manji, Hartmuth Kolb, Maura Furey, Wayne C. Drevets, Joo Heon Shin, Andrew Jaffe, Yankai Jia, Richard E. Straub, Amy Deep-Soboslay, Thomas Hyde, Joel E. Kleinman, Daniel R. Weinberger

Research output: Contribution to journal › Short survey › peer-review

43 Scopus citations

Abstract

We outline an ambitious project to characterize the genetic and epigenetic regulation of multiple facets of transcription in distinct brain regions across the human lifespan in samples of major neuropsychiatric disorders and controls. Initially focused on schizophrenia and mood disorders, the goal of this consortium is to elucidate the underlying molecular mechanisms of genetic associations with the goal of identifying novel therapeutic targets. The consortium currently consists of seven pharmaceutical companies and a not-for-profit medical research institution working as a precompetitive team to generate and analyze publicly available archival brain genomic data related to neuropsychiatric illness.

Original language	English (US)
Pages (from-to)	1078-1083
Number of pages	6
Journal	Neuron
Volume	88
Issue number	6
DOIs	https://doi.org/10.1016/j.neuron.2015.10.047
State	Published - 2015

ASJC Scopus subject areas

Neuroscience(all)

Access to Document

10.1016/j.neuron.2015.10.047

Cite this

Schubert, C. R., O'Donnell, P., Quan, J., Wendland, J. R., Xi, H. S., Winslow, A. R., Domenici, E., Essioux, L., Kam-Thong, T., Airey, D. C., Calley, J. N., Collier, D. A., Wang, H., Eastwood, B., Ebert, P., Liu, Y., Nisenbaum, L., Ruble, C., Scherschel, J., ... Weinberger, D. R. (2015). BrainSeq: Neurogenomics to Drive Novel Target Discovery for Neuropsychiatric Disorders. Neuron, 88(6), 1078-1083. https://doi.org/10.1016/j.neuron.2015.10.047

Schubert, CR, O'Donnell, P, Quan, J, Wendland, JR, Xi, HS, Winslow, AR, Domenici, E, Essioux, L, Kam-Thong, T, Airey, DC, Calley, JN, Collier, DA, Wang, H, Eastwood, B, Ebert, P, Liu, Y, Nisenbaum, L, Ruble, C, Scherschel, J, Smith, RM, Qian, HR, Merchant, K, Didriksen, M, Matsumoto, M, Saito, T, Brandon, NJ, Cross, AJ, Wang, Q, Manji, H, Kolb, H, Furey, M, Drevets, WC, Shin, JH, Jaffe, A, Jia, Y, Straub, RE, Deep-Soboslay, A, Hyde, T, Kleinman, JE & Weinberger, DR 2015, 'BrainSeq: Neurogenomics to Drive Novel Target Discovery for Neuropsychiatric Disorders', Neuron, vol. 88, no. 6, pp. 1078-1083. https://doi.org/10.1016/j.neuron.2015.10.047

@article{e9d79995337e41b9a63594c0b72b1708,

title = "BrainSeq: Neurogenomics to Drive Novel Target Discovery for Neuropsychiatric Disorders",

abstract = "We outline an ambitious project to characterize the genetic and epigenetic regulation of multiple facets of transcription in distinct brain regions across the human lifespan in samples of major neuropsychiatric disorders and controls. Initially focused on schizophrenia and mood disorders, the goal of this consortium is to elucidate the underlying molecular mechanisms of genetic associations with the goal of identifying novel therapeutic targets. The consortium currently consists of seven pharmaceutical companies and a not-for-profit medical research institution working as a precompetitive team to generate and analyze publicly available archival brain genomic data related to neuropsychiatric illness.",

author = "Schubert, {Christian R.} and Patricio O'Donnell and Jie Quan and Wendland, {Jens R.} and Xi, {Hualin S.} and Winslow, {Ashley R.} and Enrico Domenici and Laurent Essioux and Tony Kam-Thong and Airey, {David C.} and Calley, {John N.} and Collier, {David A.} and Hong Wang and Brian Eastwood and Philip Ebert and Yushi Liu and Laura Nisenbaum and Cara Ruble and James Scherschel and Smith, {Ryan Matthew} and Qian, {Hui Rong} and Kalpana Merchant and Michael Didriksen and Mitsuyuki Matsumoto and Takeshi Saito and Brandon, {Nicholas J.} and Cross, {Alan J.} and Qi Wang and Husseini Manji and Hartmuth Kolb and Maura Furey and Drevets, {Wayne C.} and Shin, {Joo Heon} and Andrew Jaffe and Yankai Jia and Straub, {Richard E.} and Amy Deep-Soboslay and Thomas Hyde and Kleinman, {Joel E.} and Weinberger, {Daniel R.}",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier Inc.",

year = "2015",

doi = "10.1016/j.neuron.2015.10.047",

language = "English (US)",

volume = "88",

pages = "1078--1083",

journal = "Neuron",

issn = "0896-6273",

publisher = "Cell Press",

number = "6",

}

TY - JOUR

T1 - BrainSeq

T2 - Neurogenomics to Drive Novel Target Discovery for Neuropsychiatric Disorders

AU - Schubert, Christian R.

AU - O'Donnell, Patricio

AU - Quan, Jie

AU - Wendland, Jens R.

AU - Xi, Hualin S.

AU - Winslow, Ashley R.

AU - Domenici, Enrico

AU - Essioux, Laurent

AU - Kam-Thong, Tony

AU - Airey, David C.

AU - Calley, John N.

AU - Collier, David A.

AU - Wang, Hong

AU - Eastwood, Brian

AU - Ebert, Philip

AU - Liu, Yushi

AU - Nisenbaum, Laura

AU - Ruble, Cara

AU - Scherschel, James

AU - Smith, Ryan Matthew

AU - Qian, Hui Rong

AU - Merchant, Kalpana

AU - Didriksen, Michael

AU - Matsumoto, Mitsuyuki

AU - Saito, Takeshi

AU - Brandon, Nicholas J.

AU - Cross, Alan J.

AU - Wang, Qi

AU - Manji, Husseini

AU - Kolb, Hartmuth

AU - Furey, Maura

AU - Drevets, Wayne C.

AU - Shin, Joo Heon

AU - Jaffe, Andrew

AU - Jia, Yankai

AU - Straub, Richard E.

AU - Deep-Soboslay, Amy

AU - Hyde, Thomas

AU - Kleinman, Joel E.

AU - Weinberger, Daniel R.

PY - 2015

Y1 - 2015

N2 - We outline an ambitious project to characterize the genetic and epigenetic regulation of multiple facets of transcription in distinct brain regions across the human lifespan in samples of major neuropsychiatric disorders and controls. Initially focused on schizophrenia and mood disorders, the goal of this consortium is to elucidate the underlying molecular mechanisms of genetic associations with the goal of identifying novel therapeutic targets. The consortium currently consists of seven pharmaceutical companies and a not-for-profit medical research institution working as a precompetitive team to generate and analyze publicly available archival brain genomic data related to neuropsychiatric illness.

AB - We outline an ambitious project to characterize the genetic and epigenetic regulation of multiple facets of transcription in distinct brain regions across the human lifespan in samples of major neuropsychiatric disorders and controls. Initially focused on schizophrenia and mood disorders, the goal of this consortium is to elucidate the underlying molecular mechanisms of genetic associations with the goal of identifying novel therapeutic targets. The consortium currently consists of seven pharmaceutical companies and a not-for-profit medical research institution working as a precompetitive team to generate and analyze publicly available archival brain genomic data related to neuropsychiatric illness.

UR - http://www.scopus.com/inward/record.url?scp=84961616869&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84961616869&partnerID=8YFLogxK

U2 - 10.1016/j.neuron.2015.10.047

DO - 10.1016/j.neuron.2015.10.047

M3 - Short survey

C2 - 26687217

AN - SCOPUS:84961616869

SN - 0896-6273

VL - 88

SP - 1078

EP - 1083

JO - Neuron

JF - Neuron

IS - 6

ER -

BrainSeq: Neurogenomics to Drive Novel Target Discovery for Neuropsychiatric Disorders

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this