Brain regulates weight bearing bone through PGE2 skeletal interoception: implication of ankle osteoarthritis and pain

Keyphrases

• Prostaglandin E2 100%
• Weight-bearing 100%
• Interoception 100%
• Ankle Pain 100%
• Ankle Osteoarthritis 100%
• Mechanical Loading 71%
• Sensory Nerves 28%
• Bone Formation 28%
• Mechanical Stress 14%
• Hypothalamus 14%
• Physiologic 14%
• TrkA 14%
• Cyclooxygenase-2 14%
• Bone Remodeling 14%
• Bone Structure 14%
• Protein Phosphorylation 14%
• Paraventricular nucleus 14%
• Mechanical Load 14%
• Potential Treatments 14%
• Hypothalamic Arcuate nucleus 14%
• Bone Cells 14%
• CAMP Response Element-binding Protein 14%
• Bone Changes 14%
• Osteogenesis 14%
• Mechanosensitive 14%
• Tyrosine Hydroxylase Expression 14%
• Tail Suspension 14%
• Bone Homeostasis 14%
• Osteoblast Lineage Cells 14%

Biochemistry, Genetics and Molecular Biology

• Prostaglandin E2 100%
• Weight Bearing 100%
• Interoception 100%
• Ossification 28%
• Mouse 14%
• Eicosanoid Receptor 14%
• Binding Protein 14%
• Mechanical Stress 14%
• Homeostasis 14%
• Response Element 14%
• Cyclooxygenase 14%
• Cyclic Adenosine Monophosphate 14%
• Protein Phosphorylation 14%
• Osteoblast 14%
• Bone Development 14%
• Tyrosine Hydroxylase 14%
• Bone Remodeling 14%

Neuroscience

• Prostaglandin E2 100%
• Afferent Nerve Fiber 28%
• Sensory Nerve 28%
• Eicosanoid Receptor 14%
• Cyclic Adenosine Monophosphate 14%
• Hypothalamus 14%
• Cyclooxygenase 2 14%
• Protein Binding 14%
• Tyrosine Hydroxylase 14%
• Arcuate Nucleus 14%
• Protein Phosphorylation 14%
• Response Element 14%