Brain PET Imaging in the Cannabinoid System

Dean F. Wong; Ayon Nandi; Eram Zaidi; Emily Gean; Andrew Horti; Boris Frolov; Noble George; James R. Brasic

doi:10.1016/B978-0-12-418677-4.00002-6

Brain PET Imaging in the Cannabinoid System

Dean F. Wong, Ayon Nandi, Eram Zaidi, Emily Gean, Andrew Horti, Boris Frolov, Noble George, James R. Brasic

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

The cannabinoid system constitutes a key entity throughout the human body. The cannabinoid type 1 receptor (CB₁R), the prominent cannabinoid component in the brain, interacts significantly with the dopaminergic system and its role in reward. CB₁Rs have been implicated in "reward disorders" such as obesity and substance abuse, as well as in schizophrenia and mood disorders. The further exploration of the role of these receptors is important for a general knowledge of the brain and, ultimately, for the development of drugs to target associated diseases. Positron emission tomography (PET) imaging allows for the investigation of specific receptors in vivo. PET radioligands targeted to the specific receptor type are essential. The development of effective radiotracers for imaging CB₁R has been met with challenges, due to poor blood brain permeability, nonspecificity and fast washout. The current chapter provides a review of the three CB₁R PET radioligands available for use to investigate the cannabinoid system in humans in health and disease.

Original language	English (US)
Title of host publication	Imaging of the Human Brain in Health and Disease
Publisher	Elsevier Inc.
Pages	27-36
Number of pages	10
ISBN (Print)	9780124186774
DOIs	https://doi.org/10.1016/B978-0-12-418677-4.00002-6
State	Published - 2014

Keywords

Cannabinoid
Depression
Drug abuse
Eating disorder
Marijuana
PET
PTSD\
Post-traumatic Stress disorder
Schizophrenia

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/B978-0-12-418677-4.00002-6

Cite this

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title = "Brain PET Imaging in the Cannabinoid System",

abstract = "The cannabinoid system constitutes a key entity throughout the human body. The cannabinoid type 1 receptor (CB1R), the prominent cannabinoid component in the brain, interacts significantly with the dopaminergic system and its role in reward. CB1Rs have been implicated in {"}reward disorders{"} such as obesity and substance abuse, as well as in schizophrenia and mood disorders. The further exploration of the role of these receptors is important for a general knowledge of the brain and, ultimately, for the development of drugs to target associated diseases. Positron emission tomography (PET) imaging allows for the investigation of specific receptors in vivo. PET radioligands targeted to the specific receptor type are essential. The development of effective radiotracers for imaging CB1R has been met with challenges, due to poor blood brain permeability, nonspecificity and fast washout. The current chapter provides a review of the three CB1R PET radioligands available for use to investigate the cannabinoid system in humans in health and disease.",

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AU - Wong, Dean F.

AU - Nandi, Ayon

AU - Zaidi, Eram

AU - Gean, Emily

AU - Horti, Andrew

AU - Frolov, Boris

AU - George, Noble

AU - Brasic, James R.

PY - 2014

Y1 - 2014

N2 - The cannabinoid system constitutes a key entity throughout the human body. The cannabinoid type 1 receptor (CB1R), the prominent cannabinoid component in the brain, interacts significantly with the dopaminergic system and its role in reward. CB1Rs have been implicated in "reward disorders" such as obesity and substance abuse, as well as in schizophrenia and mood disorders. The further exploration of the role of these receptors is important for a general knowledge of the brain and, ultimately, for the development of drugs to target associated diseases. Positron emission tomography (PET) imaging allows for the investigation of specific receptors in vivo. PET radioligands targeted to the specific receptor type are essential. The development of effective radiotracers for imaging CB1R has been met with challenges, due to poor blood brain permeability, nonspecificity and fast washout. The current chapter provides a review of the three CB1R PET radioligands available for use to investigate the cannabinoid system in humans in health and disease.

AB - The cannabinoid system constitutes a key entity throughout the human body. The cannabinoid type 1 receptor (CB1R), the prominent cannabinoid component in the brain, interacts significantly with the dopaminergic system and its role in reward. CB1Rs have been implicated in "reward disorders" such as obesity and substance abuse, as well as in schizophrenia and mood disorders. The further exploration of the role of these receptors is important for a general knowledge of the brain and, ultimately, for the development of drugs to target associated diseases. Positron emission tomography (PET) imaging allows for the investigation of specific receptors in vivo. PET radioligands targeted to the specific receptor type are essential. The development of effective radiotracers for imaging CB1R has been met with challenges, due to poor blood brain permeability, nonspecificity and fast washout. The current chapter provides a review of the three CB1R PET radioligands available for use to investigate the cannabinoid system in humans in health and disease.

KW - Cannabinoid

KW - Depression

KW - Drug abuse

KW - Eating disorder

KW - Marijuana

KW - PET

KW - PTSD\

KW - Post-traumatic Stress disorder

KW - Schizophrenia

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BT - Imaging of the Human Brain in Health and Disease

PB - Elsevier Inc.

ER -

Brain PET Imaging in the Cannabinoid System

Abstract

Keywords

ASJC Scopus subject areas

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