TY - JOUR
T1 - Brain Oxygen Extraction and Metabolism in Pediatric Patients With Sickle Cell Disease
T2 - Comparison of Four Calibration Models
AU - Lin, Zixuan
AU - McIntyre, Tiffany
AU - Jiang, Dengrong
AU - Cannon, Alicia
AU - Liu, Peiying
AU - Tekes, Aylin
AU - Casella, James F.
AU - Slifer, Keith
AU - Lu, Hanzhang
AU - Lance, Eboni
N1 - Funding Information:
This work was supported by the National Institutes of Health (Nih) grant R01 Ag064792, Rf1 Ag071515, R01 Ns106711, R01 Ns106702, P41 Eb015909, P41 Eb031771, S10 Od021648, K23 Hl133455-01A1, U54 Hd079123, and P50 Hd103538.
Publisher Copyright:
Copyright © 2022 Lin, McIntyre, Jiang, Cannon, Liu, Tekes, Casella, Slifer, Lu and Lance.
PY - 2022/2/11
Y1 - 2022/2/11
N2 - Sickle cell disease (SCD) is an inherited hemoglobinopathy with an increased risk of neurological complications. Due to anemia and other factors related to the underlying hemoglobinopathy, cerebral blood flow (CBF) increases as compensation; however, the nature of alterations in oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen (CMRO2) in SCD remains controversial, largely attributed to the different calibration models. In addition, limited studies have been done to investigate oxygen metabolism in pediatric patients. Thus, this study used a non-invasive T2-based MR oximetry, T2-Relaxation-Under-Spin-Tagging (TRUST) MRI, to measure oxygen homeostasis in pediatric patients with SCD using four different calibration models and examined its relationship to hematological measures. It was found that, compared with controls, SCD patients showed an increased CBF, unchanged total oxygen delivery and increased venous blood T2. The results of OEF and CMRO2 were dependent on the calibration models used. When using sickle-specific, hemoglobin S (HbS) level-dependent calibration, there was a decreased OEF and CMRO2, while the bovine model showed an opposite result. OEF and CMRO2 were also associated with hemoglobin and HbS level; the direction of the relationship was again dependent on the model. Future studies with in vivo calibration are needed to provide more accurate information on the T2-Yv relationship.
AB - Sickle cell disease (SCD) is an inherited hemoglobinopathy with an increased risk of neurological complications. Due to anemia and other factors related to the underlying hemoglobinopathy, cerebral blood flow (CBF) increases as compensation; however, the nature of alterations in oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen (CMRO2) in SCD remains controversial, largely attributed to the different calibration models. In addition, limited studies have been done to investigate oxygen metabolism in pediatric patients. Thus, this study used a non-invasive T2-based MR oximetry, T2-Relaxation-Under-Spin-Tagging (TRUST) MRI, to measure oxygen homeostasis in pediatric patients with SCD using four different calibration models and examined its relationship to hematological measures. It was found that, compared with controls, SCD patients showed an increased CBF, unchanged total oxygen delivery and increased venous blood T2. The results of OEF and CMRO2 were dependent on the calibration models used. When using sickle-specific, hemoglobin S (HbS) level-dependent calibration, there was a decreased OEF and CMRO2, while the bovine model showed an opposite result. OEF and CMRO2 were also associated with hemoglobin and HbS level; the direction of the relationship was again dependent on the model. Future studies with in vivo calibration are needed to provide more accurate information on the T2-Yv relationship.
KW - CBF
KW - CMRO
KW - OEF
KW - TRUST MRI
KW - sickle cell disease
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U2 - 10.3389/fphys.2022.814979
DO - 10.3389/fphys.2022.814979
M3 - Article
C2 - 35222083
AN - SCOPUS:85124883456
SN - 1664-042X
VL - 13
JO - Frontiers in Physiology
JF - Frontiers in Physiology
M1 - 814979
ER -