Brain-based correlates of antidepressant response to ketamine: a comprehensive systematic review of neuroimaging studies

Gustavo C. Medeiros, Malcolm Matheson, Isabella Demo, Matthew J. Reid, Sharaya Matheson, Claire Twose, Gwenn S. Smith, Todd D. Gould, Carlos A. Zarate, Frederick S. Barrett, Fernando S. Goes

Research output: Contribution to journalReview articlepeer-review

Abstract

Ketamine is an effective antidepressant, but there is substantial variability in patient response and the precise mechanism of action is unclear. Neuroimaging can provide predictive and mechanistic insights, but findings are limited by small sample sizes. This systematic review covers neuroimaging studies investigating baseline (pre-treatment) and longitudinal (post-treatment) biomarkers of responses to ketamine. All modalities were included. We performed searches of five electronic databases (from inception to April 26, 2022). 69 studies were included (with 1751 participants). There was substantial methodological heterogeneity and no well replicated biomarker. However, we found convergence across some significant results, particularly in longitudinal biomarkers. Response to ketamine was associated with post-treatment increases in gamma power in frontoparietal regions in electrophysiological studies, post-treatment increases in functional connectivity within the prefrontal cortex, and post-treatment increases in the functional activation of the striatum. Although a well replicated neuroimaging biomarker of ketamine response was not identified, there are biomarkers that warrant further investigation.

Original languageEnglish (US)
Pages (from-to)790-800
Number of pages11
JournalThe Lancet Psychiatry
Volume10
Issue number10
DOIs
StatePublished - Oct 2023

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Fingerprint

Dive into the research topics of 'Brain-based correlates of antidepressant response to ketamine: a comprehensive systematic review of neuroimaging studies'. Together they form a unique fingerprint.

Cite this