Bradykinin stimulates tumor necrosis factor and interleukin-1 release from macrophages

Carol W. Tiffany, Ronald M. Burch

Research output: Contribution to journalArticlepeer-review

204 Scopus citations


Bradykinin and related kinins have been implicated in the initiation and maintenance of inflammation. Cytokines appear to be the primary mediators of many inflammatory diseases. The potential ability of bradykinin to stimulate release of tumor necrosis factor and interleukin-1 from macrophages was examined. Bradykinin stimulated release of both cytokines from P388-D1 and RAW264.7 murine macrophages. Studies with selective agonists and antagonists suggest that cytokine release is mediated by a B1 kinin receptor.

Original languageEnglish (US)
Pages (from-to)189-192
Number of pages4
JournalFEBS Letters
Issue number2
StatePublished - Apr 24 1989
Externally publishedYes


  • Bradykinin
  • Bradykinin antagonist
  • Cytokine
  • Interleukin-1
  • Macrophage
  • Tumor necrosis factor

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology


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