TY - JOUR
T1 - Brachial-ankle pulse wave velocity is associated with coronary calcium in young and middle-aged asymptomatic adults
T2 - The Kangbuk Samsung Health Study
AU - Cainzos-Achirica, Miguel
AU - Rampal, Sanjay
AU - Chang, Yoosoo
AU - Ryu, Seungho
AU - Zhang, Yiyi
AU - Zhao, Di
AU - Cho, Juhee
AU - Choi, Yuni
AU - Pastor-Barriuso, Roberto
AU - Lim, So Yeon
AU - Bruguera, Jordi
AU - Elosua, Roberto
AU - Lima, Joao A.C.
AU - Shin, Hocheol
AU - Guallar, Eliseo
N1 - Funding Information:
Miguel Cainzos-Achirica was funded by a research grant from the Spanish Society of Cardiology .
Publisher Copyright:
© 2015.
PY - 2015/8/1
Y1 - 2015/8/1
N2 - Objective: To evaluate the association between brachial-ankle pulse wave velocity (baPWV), a convenient, non-radiating, readily available measurement of arterial stiffness, and coronary artery calcium (CAC), a reliable marker of coronary atherosclerosis, in a large sample of young and middle-aged asymptomatic adults; and to assess the incremental value of baPWV for detecting prevalent CAC beyond traditional risk factors. Methods: Cross-sectional study of 15,185 asymptomatic Korean adults who voluntarily underwent a comprehensive health screening program including measurement of baPWV and CAC. BaPWV was measured using an oscillometric method with cuffs placed on both arms and ankles. CAC burden was assessed using a multi-detector CT scan and scored following Agatston's method. Results: The prevalence of CAC > 0 and CAC > 100 increased across baPWV quintiles. The multivariable-adjusted odds ratios (95% CI) for CAC > 0 comparing baPWV quintiles 2-5 versus quintile 1 were 1.06 (0.87-1.30), 1.24 (1.02-1.50), 1.39 (1.15-1.69) and 1.60 (1.31-1.96), respectively (P trend < 0.001). Similarly, the relative prevalence ratios for CAC > 100 were 1.30 (0.74-2.26), 1.59 (0.93-2.71), 1.74 (1.03-2.94) and 2.59 (1.54-4.36), respectively (P trend < 0.001). For CAC > 100, the area under the ROC curve for baPWV alone was 0.71 (0.68-0.74), and the addition of baPWV to traditional risk factors significantly improved the , and calibration of models for detecting prevalent CAC > 0 and CAC > 100. Conclusions: BaPWV was independently associated with the presence and severity of CAC in a large sample of young and middle-aged asymptomatic adults. BaPWV may be a valuable tool for identifying apparently low-risk individuals with increased burden of coronary atherosclerosis.
AB - Objective: To evaluate the association between brachial-ankle pulse wave velocity (baPWV), a convenient, non-radiating, readily available measurement of arterial stiffness, and coronary artery calcium (CAC), a reliable marker of coronary atherosclerosis, in a large sample of young and middle-aged asymptomatic adults; and to assess the incremental value of baPWV for detecting prevalent CAC beyond traditional risk factors. Methods: Cross-sectional study of 15,185 asymptomatic Korean adults who voluntarily underwent a comprehensive health screening program including measurement of baPWV and CAC. BaPWV was measured using an oscillometric method with cuffs placed on both arms and ankles. CAC burden was assessed using a multi-detector CT scan and scored following Agatston's method. Results: The prevalence of CAC > 0 and CAC > 100 increased across baPWV quintiles. The multivariable-adjusted odds ratios (95% CI) for CAC > 0 comparing baPWV quintiles 2-5 versus quintile 1 were 1.06 (0.87-1.30), 1.24 (1.02-1.50), 1.39 (1.15-1.69) and 1.60 (1.31-1.96), respectively (P trend < 0.001). Similarly, the relative prevalence ratios for CAC > 100 were 1.30 (0.74-2.26), 1.59 (0.93-2.71), 1.74 (1.03-2.94) and 2.59 (1.54-4.36), respectively (P trend < 0.001). For CAC > 100, the area under the ROC curve for baPWV alone was 0.71 (0.68-0.74), and the addition of baPWV to traditional risk factors significantly improved the , and calibration of models for detecting prevalent CAC > 0 and CAC > 100. Conclusions: BaPWV was independently associated with the presence and severity of CAC in a large sample of young and middle-aged asymptomatic adults. BaPWV may be a valuable tool for identifying apparently low-risk individuals with increased burden of coronary atherosclerosis.
KW - Arterial stiffness
KW - Atherosclerosis
KW - Coronary artery calcium
KW - Pulse wave velocity
KW - Subclinical disease
UR - http://www.scopus.com/inward/record.url?scp=84936804815&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84936804815&partnerID=8YFLogxK
U2 - 10.1016/j.atherosclerosis.2015.05.031
DO - 10.1016/j.atherosclerosis.2015.05.031
M3 - Article
C2 - 26071657
AN - SCOPUS:84936804815
SN - 0021-9150
VL - 241
SP - 350
EP - 356
JO - Atherosclerosis
JF - Atherosclerosis
IS - 2
ER -