Bortezomib treatment for refractory nontuberculous mycobacterial infection in the setting of interferon gamma autoantibodies

Joseph M. Rocco; Lindsey B. Rosen; Gloria H. Hong; Jennifer Treat; Samantha Kreuzburg; Steven M. Holland; Christa S. Zerbe

doi:10.1016/j.jtauto.2021.100102

Bortezomib treatment for refractory nontuberculous mycobacterial infection in the setting of interferon gamma autoantibodies

Joseph M. Rocco, Lindsey B. Rosen, Gloria H. Hong, Jennifer Treat, Samantha Kreuzburg, Steven M. Holland, Christa S. Zerbe

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Interferon-γ autoantibodies increase the risk of disseminated nontuberculous mycobacterial infections. Addition of rituximab to antibiotics accelerates and improves outcomes, but refractory infections can occur due to persistent production of autoantibodies. We combined bortezomib with rituximab to reduce autoantibodies leading to clinical and radiographic improvement in infection.

Original language	English (US)
Article number	100102
Journal	Journal of Translational Autoimmunity
Volume	4
DOIs	https://doi.org/10.1016/j.jtauto.2021.100102
State	Published - Jan 2021

Keywords

Autoantibodies
Bortezomib
Interferon gamma
Nontuberculous mycobacteria
Rituximab

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/j.jtauto.2021.100102

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title = "Bortezomib treatment for refractory nontuberculous mycobacterial infection in the setting of interferon gamma autoantibodies",

abstract = "Interferon-γ autoantibodies increase the risk of disseminated nontuberculous mycobacterial infections. Addition of rituximab to antibiotics accelerates and improves outcomes, but refractory infections can occur due to persistent production of autoantibodies. We combined bortezomib with rituximab to reduce autoantibodies leading to clinical and radiographic improvement in infection.",

keywords = "Autoantibodies, Bortezomib, Interferon gamma, Nontuberculous mycobacteria, Rituximab",

author = "Rocco, {Joseph M.} and Rosen, {Lindsey B.} and Hong, {Gloria H.} and Jennifer Treat and Samantha Kreuzburg and Holland, {Steven M.} and Zerbe, {Christa S.}",

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year = "2021",

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doi = "10.1016/j.jtauto.2021.100102",

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AU - Rocco, Joseph M.

AU - Rosen, Lindsey B.

AU - Hong, Gloria H.

AU - Treat, Jennifer

AU - Kreuzburg, Samantha

AU - Holland, Steven M.

AU - Zerbe, Christa S.

PY - 2021/1

Y1 - 2021/1

N2 - Interferon-γ autoantibodies increase the risk of disseminated nontuberculous mycobacterial infections. Addition of rituximab to antibiotics accelerates and improves outcomes, but refractory infections can occur due to persistent production of autoantibodies. We combined bortezomib with rituximab to reduce autoantibodies leading to clinical and radiographic improvement in infection.

AB - Interferon-γ autoantibodies increase the risk of disseminated nontuberculous mycobacterial infections. Addition of rituximab to antibiotics accelerates and improves outcomes, but refractory infections can occur due to persistent production of autoantibodies. We combined bortezomib with rituximab to reduce autoantibodies leading to clinical and radiographic improvement in infection.

KW - Autoantibodies

KW - Bortezomib

KW - Interferon gamma

KW - Nontuberculous mycobacteria

KW - Rituximab

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M3 - Article

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JO - Journal of Translational Autoimmunity

JF - Journal of Translational Autoimmunity

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ER -

Bortezomib treatment for refractory nontuberculous mycobacterial infection in the setting of interferon gamma autoantibodies

Abstract

Keywords

ASJC Scopus subject areas

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