Border-cell migration: The race is on

Denise J. Montell

doi:10.1038/nrm1006

Border-cell migration: The race is on

Denise J. Montell

Research output: Contribution to journal › Review article › peer-review

224 Scopus citations

Abstract

The conversion of stationary epithelial cells into migratory, invasive cells is important for normal embryonic development and tumour metastasis. Border-cell migration in the ovary of Drosophila melanogaster has emerged as a simple, genetically tractable model for studying this process. Three distinct signals, which are also upregulated in cancer, control border-cell migration, so identifying further genes that are involved in border-cell migration could provide new insights into tumour invasion.

Original language	English (US)
Pages (from-to)	13-24
Number of pages	12
Journal	Nature Reviews Molecular Cell Biology
Volume	4
Issue number	1
DOIs	https://doi.org/10.1038/nrm1006
State	Published - Jan 1 2003
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.1038/nrm1006

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title = "Border-cell migration: The race is on",

abstract = "The conversion of stationary epithelial cells into migratory, invasive cells is important for normal embryonic development and tumour metastasis. Border-cell migration in the ovary of Drosophila melanogaster has emerged as a simple, genetically tractable model for studying this process. Three distinct signals, which are also upregulated in cancer, control border-cell migration, so identifying further genes that are involved in border-cell migration could provide new insights into tumour invasion.",

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AB - The conversion of stationary epithelial cells into migratory, invasive cells is important for normal embryonic development and tumour metastasis. Border-cell migration in the ovary of Drosophila melanogaster has emerged as a simple, genetically tractable model for studying this process. Three distinct signals, which are also upregulated in cancer, control border-cell migration, so identifying further genes that are involved in border-cell migration could provide new insights into tumour invasion.

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Border-cell migration: The race is on

Abstract

ASJC Scopus subject areas

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