Boosting of Voriconazole Levels With Omeprazole, A CYP450 2C19 Inhibitor

Alice J. Hsu; Carlton K Lee; John Mcateer; Sean X. Zhang; Pranita D. Tamma

doi:10.1097/INF.0000000000003898

Boosting of Voriconazole Levels With Omeprazole, A CYP450 2C19 Inhibitor

Alice J. Hsu, Carlton K Lee, John Mcateer, Sean X. Zhang, Pranita D. Tamma

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Children metabolize voriconazole faster than adults and require higher weight-based doses and more frequent administration to achieve therapeutic troughs. We report a case of a 4-year-old girl with disseminated fusariosis with persistently undetectable voriconazole troughs. Omeprazole was added as a CYP2C19-inhibitor to increase voriconazole concentrations. This case highlights the role of omeprazole for voriconazole boosting in a child.

Original language	English (US)
Pages (from-to)	485-488
Number of pages	4
Journal	Pediatric Infectious Disease Journal
Volume	42
Issue number	6
DOIs	https://doi.org/10.1097/INF.0000000000003898
State	Published - Jun 1 2023

Keywords

CYP450 2C19 inhibitor
fusariosis
omeprazole
therapeutic drug monitoring
voriconazole

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Microbiology (medical)
Infectious Diseases

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10.1097/INF.0000000000003898

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abstract = "Children metabolize voriconazole faster than adults and require higher weight-based doses and more frequent administration to achieve therapeutic troughs. We report a case of a 4-year-old girl with disseminated fusariosis with persistently undetectable voriconazole troughs. Omeprazole was added as a CYP2C19-inhibitor to increase voriconazole concentrations. This case highlights the role of omeprazole for voriconazole boosting in a child.",

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AU - Tamma, Pranita D.

PY - 2023/6/1

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AB - Children metabolize voriconazole faster than adults and require higher weight-based doses and more frequent administration to achieve therapeutic troughs. We report a case of a 4-year-old girl with disseminated fusariosis with persistently undetectable voriconazole troughs. Omeprazole was added as a CYP2C19-inhibitor to increase voriconazole concentrations. This case highlights the role of omeprazole for voriconazole boosting in a child.

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KW - therapeutic drug monitoring

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Boosting of Voriconazole Levels With Omeprazole, A CYP450 2C19 Inhibitor

Abstract

Keywords

ASJC Scopus subject areas

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