“Bone-SASP” in Skeletal Aging

Ching Lien Fang, Bin Liu, Mei Wan

Research output: Contribution to journalReview articlepeer-review

Abstract

Senescence is a complex cell state characterized by stable cell cycle arrest and a unique secretory pattern known as the senescence-associated secretory phenotype (SASP). The SASP factors, which are heterogeneous and tissue specific, normally include chemokines, cytokines, growth factors, adhesion molecules, and lipid components that can lead to multiple age-associated disorders by eliciting local and systemic consequences. The skeleton is a highly dynamic organ that changes constantly in shape and composition. Senescent cells in bone and bone marrow produce diverse SASP factors that induce alterations of the skeleton through paracrine effects. Herein, we refer to bone cell-associated SASP as “bone-SASP.” In this review, we describe current knowledge of cellular senescence and SASP, focusing on the role of senescent cells in mediating bone pathologies during natural aging and premature aging syndromes. We also summarize the role of cellular senescence and the bone-SASP in glucocorticoids-induced bone damage. In addition, we discuss the role of bone-SASP in the development of osteoarthritis, highlighting the mechanisms by which bone-SASP drives subchondral bone changes in metabolic syndrome-associated osteoarthritis.

Original languageEnglish (US)
Pages (from-to)68-82
Number of pages15
JournalCalcified Tissue International
Volume113
Issue number1
DOIs
StatePublished - Jul 2023

Keywords

  • Bone-SASP
  • Cellular senescence
  • Osteoarthritis
  • Osteoporosis
  • Premature aging syndromes
  • Progeria syndrome
  • Senescence-associated secretory phenotype (SASP)
  • Skeletal aging

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine
  • Endocrinology

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