TY - JOUR
T1 - Bone Microvasculature
T2 - Stimulus for Tissue Function and Regeneration
AU - Lee, Eun Jin
AU - Jain, Mahim
AU - Alimperti, Stella
N1 - Funding Information:
This work was supported by the American Dental Association Science and Research Institute and American Dental Association Foundation grant (97700142) and the National Institute of Arthritis And Musculoskeletal And Skin Diseases of the National Institutes of Health (R21AR076497).
Publisher Copyright:
© Copyright 2021, Mary Ann Liebert, Inc., publishers 2021.
PY - 2021/8/1
Y1 - 2021/8/1
N2 - Bone is a highly vascularized organ, providing structural support to the body, and its development, regeneration, and remodeling depend on the microvascular homeostasis. Loss or impairment of vascular function can develop diseases, such as large bone defects, avascular necrosis, osteoporosis, osteoarthritis, and osteopetrosis. In this review, we summarize how vasculature controls bone development and homeostasis in normal and disease cases. A better understanding of this process will facilitate the development of novel disease treatments that promote bone regeneration and remodeling. Specifically, approaches based on tissue engineering components, such as stem cells and growth factors, have demonstrated the capacity to induce bone microvasculature regeneration and mineralization. This knowledge will have relevant clinical implications for the treatment of bone disorders by developing novel pharmaceutical approaches and bone grafts. Finally, the tissue engineering approaches incorporating vascular components may widely be applied to treat other organ diseases by enhancing their regeneration capacity. Bone vasculature is imperative in the process of bone development, regeneration, and remodeling. Alterations or disruption of the bone vasculature leads to loss of bone homeostasis and the development of bone diseases. In this study, we review the role of vasculature on bone diseases and how vascular tissue engineering strategies, with a detailed emphasis on the role of stem cells and growth factors, will contribute to bone therapeutics.
AB - Bone is a highly vascularized organ, providing structural support to the body, and its development, regeneration, and remodeling depend on the microvascular homeostasis. Loss or impairment of vascular function can develop diseases, such as large bone defects, avascular necrosis, osteoporosis, osteoarthritis, and osteopetrosis. In this review, we summarize how vasculature controls bone development and homeostasis in normal and disease cases. A better understanding of this process will facilitate the development of novel disease treatments that promote bone regeneration and remodeling. Specifically, approaches based on tissue engineering components, such as stem cells and growth factors, have demonstrated the capacity to induce bone microvasculature regeneration and mineralization. This knowledge will have relevant clinical implications for the treatment of bone disorders by developing novel pharmaceutical approaches and bone grafts. Finally, the tissue engineering approaches incorporating vascular components may widely be applied to treat other organ diseases by enhancing their regeneration capacity. Bone vasculature is imperative in the process of bone development, regeneration, and remodeling. Alterations or disruption of the bone vasculature leads to loss of bone homeostasis and the development of bone diseases. In this study, we review the role of vasculature on bone diseases and how vascular tissue engineering strategies, with a detailed emphasis on the role of stem cells and growth factors, will contribute to bone therapeutics.
KW - angiogenesis
KW - bone vasculature
KW - diseases
KW - growth factors
KW - osteogenesis
KW - stem cells
KW - tissue engineering
UR - http://www.scopus.com/inward/record.url?scp=85112865709&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85112865709&partnerID=8YFLogxK
U2 - 10.1089/ten.teb.2020.0154
DO - 10.1089/ten.teb.2020.0154
M3 - Review article
C2 - 32940150
AN - SCOPUS:85112865709
SN - 1937-3368
VL - 27
SP - 313
EP - 329
JO - Tissue Engineering - Part B: Reviews
JF - Tissue Engineering - Part B: Reviews
IS - 4
ER -