Bone Marrow Transplantation for Acute Myeloid Leukemia in Children

Allen R. Chen, Robert Arceci

Research output: Chapter in Book/Report/Conference proceedingChapter


Acute myeloid leukemia (AML) was one of the first indications for bone marrow transplantation (BMT). The Seattle experience with HLA-identical sibling BMT for refractory acute leukemia from 1971 to 1975 included 54 patients with AML (1). Of this initial cohort, seven patients survived more than 18 months after BMT, including five very long-term survivors who remained in continuous complete remission 20 years after BMT. These results demonstrated the curative potential of high-dose cyclophosphamide (Cy) and total body irradiation (TBI) with marrow transplantation for chemotherapy-refractory AML.

Original languageEnglish (US)
Title of host publicationPediatric Hematopoietic Stem Cell Transplantation
PublisherCRC Press
Number of pages32
ISBN (Electronic)9780849358807
ISBN (Print)9780824724450
StatePublished - Jan 1 2006

ASJC Scopus subject areas

  • General Medicine


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