Bone Marrow Failure Disorders in the Adolescent Female

Bone marrow failure is a collective term used to describe a group of disorders which impair normal hematopoiesis, resulting in single or multiple blood cytopenias. Bone marrow failure varies in the degree and extent of its severity. There is a wide differential involved in evaluating and treating an adolescent female with bone marrow failure, and in this chapter, we are aiming to review the importance of establishing the inciting cause of marrow failure followed by focused discussion on the better studied and described genetic and acquired disorders associated with marrow failure. Details pertaining to the adolescent female are highlighted when relevant.